左亚叶酸钙、甲钴胺和 N-乙酰半胱氨酸治疗阿尔茨海默病相关认知能力下降。
L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.
机构信息
Cardiff University, Cardiff School of Medicine, North Wales, United Kingdom.
出版信息
CNS Spectr. 2010 Jan;15(1 Suppl 1):2-5; discussion 6. doi: 10.1017/s1092852900027589.
PMID:20397369
Abstract
Neuroinflammatory oxidative stress occurs early in AD pathology. Elevated blood Hcy is a useful marker for such neuroinflammation. Hcy contributes to pathological cascades involving AP and NFTs. In AD, Hcy should be lowered by B-vitamin supplements and NAC.
摘要
神经炎症性氧化应激发生在 AD 病理的早期。升高的血液 Hcy 是神经炎症的有用标志物。Hcy 有助于涉及 AP 和 NFT 的病理级联反应。在 AD 中，Hcy 应该通过 B 族维生素补充剂和 NAC 来降低。
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