School of Chemistry and University Research Centre in Catalysis and Intensified Processing, Bedson Building, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.
Org Lett. 2010 May 21;12(10):2378-81. doi: 10.1021/ol1007313.
Proline-catalyzed aldol reactions between enolizable ketones and aromatic aldehydes can be carried out in propylene carbonate. When enantiomerically pure propylene carbonate is used, the combination of (R)-proline and (R)-propylene carbonate constitutes a matched pair, while (S)-proline and (R)-propylene carbonate constitutes a mismatched pair.
脯氨酸催化烯醇化酮和芳香醛之间的Aldol 反应可以在碳酸丙烯酯中进行。当使用对映体纯的碳酸丙烯酯时，(R)-脯氨酸和(R)-碳酸丙烯酯的组合构成匹配对，而(S)-脯氨酸和(R)-碳酸丙烯酯的组合构成不匹配对。
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