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在环状碳酸酯溶剂中脯氨酸催化的胺化反应。

Proline-catalysed amination reactions in cyclic carbonate solvents.

机构信息

School of Chemistry, Research Centre in Catalysis and Intensified Processing, Bedson Building, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK.

出版信息

Molecules. 2011 Apr 21;16(4):3420-32. doi: 10.3390/molecules16043420.

DOI:10.3390/molecules16043420
PMID:21512450
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6260617/
Abstract

Propylene carbonate is shown to be an environmentally friendly and sustainable replacement for dichloromethane and acetonitrile in proline-catalysed a-hydrazinations of aldehydes and ketones. Enantioselectivities comparable to those obtained in conventional solvents or ionic liquids can be obtained, even when using a lower catalyst loading.

摘要

碳酸丙烯酯被证明是一种环保且可持续的替代物，可替代二氯甲烷和乙腈，用于脯氨酸催化的醛和酮的 a-腙化反应。即使使用较低的催化剂负载量，也可以获得与传统溶剂或离子液体中获得的对映选择性相当的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/ae56220e6b06/molecules-16-03420-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/375c4ec827ca/molecules-16-03420-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/70326ad11797/molecules-16-03420-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/9efc99bee2df/molecules-16-03420-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/9ad9c9009f99/molecules-16-03420-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/ae56220e6b06/molecules-16-03420-sch004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/375c4ec827ca/molecules-16-03420-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/70326ad11797/molecules-16-03420-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/9efc99bee2df/molecules-16-03420-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/9ad9c9009f99/molecules-16-03420-sch003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/11b6/6260617/ae56220e6b06/molecules-16-03420-sch004.jpg

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