Goumba Charles M, Yandoko-Nakouné Emmanuel R, Komas Narcisse P
Viral Hepatitis Laboratory, Institut Pasteur de Bangui, Avenue de l'Indépendance x Rue Louis Pasteur, PO Box 923, Bangui, Central African Republic.
BMC Res Notes. 2010 Apr 15;3:103. doi: 10.1186/1756-0500-3-103.
Hepatitis E virus (HEV) is a major public health problem in developing countries. HEV infection in pregnant women is more common and more often fatal in the third trimester. The mortality rate due to HEV-induced hepatitis is as high as 15-20 per cent. The present study was designed to determine the potential factors responsible for high mortality rate among pregnant women.
Twenty one pregnant women attended the Maternity Center of Begoua in the Central African Republic during an outbreak of hepatitis E virus between July and October 2002 with symptoms of acute liver disease. Their mean gestational period was 29.9 (SD 8.3 weeks) and they were aged from 15 to 39 years old. The serology IgM showed that seven women (33%) had acute hepatitis E. Among them, one woman, aged 35 and her newborn died after an apparently normal preterm delivery. The 6 remaining young women, age 18 - 22, had preterm deliveries which included three live babies and three stillborn with one macerated.
These results suggest that maternal age, in addition to hormonal, immunological and environmental factors, may be a risk factor for fatal outcome.
戊型肝炎病毒（HEV）是发展中国家的一个主要公共卫生问题。孕妇感染戊型肝炎更为常见，且在妊娠晚期往往更易致命。戊型肝炎所致肝炎的死亡率高达15%至20%。本研究旨在确定导致孕妇高死亡率的潜在因素。
2002年7月至10月戊型肝炎病毒爆发期间，21名孕妇前往中非共和国贝戈阿妇产中心就诊，均有急性肝病症状。她们的平均妊娠期为29.9周（标准差8.3周），年龄在15至39岁之间。血清学IgM检测显示，7名女性（33%）患有急性戊型肝炎。其中，一名35岁的女性及其新生儿在一次看似正常的早产之后死亡。其余6名年龄在18至22岁的年轻女性发生了早产，其中有3名活产婴儿和3名死产婴儿，其中1名已浸软。
这些结果表明，除了激素、免疫和环境因素外，母亲年龄可能是导致致命结局的一个风险因素。
