Ifeorah I M, Faleye T O C, Bakarey A S, Adewumi M O, Akere A, Omoruyi E C, Ogunwale A O, Adeniji J A
Department of Medical Laboratory Sciences, Faculty of Health Science and Technology, College of Medicine, University of Nigeria, Nsukka, Nigeria.
Department of Microbiology, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria.
J Pathog. 2017;2017:4067108. doi: 10.1155/2017/4067108. Epub 2017 Dec 13.
Hepatitis E virus (HEV) remains a major public health concern in resource limited regions of the world. Yet data reporting is suboptimal and surveillance system is inadequate. In Nigeria, there is dearth of information on prevalence of acute HEV infection. This study was therefore designed to describe acute HEV infection among antenatal clinic attendees and community dwellers from two geographical regions in Nigeria. Seven hundred and fifty plasma samples were tested for HEV IgM by Enzyme Linked Immunosorbent Assay (ELISA) technique. The tested samples were randomly selected from a pool of 1,115 blood specimens previously collected for viral hepatitis studies among selected populations (pregnant women, 272; Oyo community dwellers, 438; Anambra community dwellers, 405) between September 2012 and August 2013. One (0.4%) pregnant woman in her 3rd trimester had detectable HEV IgM, while community dwellers from the two study locations had zero prevalence rates of HEV IgM. Detection of HEV IgM in a pregnant woman, especially in her 3rd trimester, is of clinical and epidemiological significance. The need therefore exists for establishment of a robust HEV surveillance system in Nigeria and especially amidst the pregnant population in a bid to improve maternal and child health.
戊型肝炎病毒（HEV）仍是世界资源有限地区主要的公共卫生问题。然而，数据报告并不理想，监测系统也不完善。在尼日利亚，关于急性戊型肝炎病毒感染患病率的信息匮乏。因此，本研究旨在描述尼日利亚两个地理区域产前诊所就诊者和社区居民中的急性戊型肝炎病毒感染情况。采用酶联免疫吸附测定（ELISA）技术对750份血浆样本进行戊型肝炎病毒IgM检测。这些检测样本是从2012年9月至2013年8月期间为选定人群（孕妇272人、奥约社区居民438人、阿南布拉社区居民405人）进行的病毒性肝炎研究中预先收集的1115份血液标本中随机选取的。一名处于孕晚期的孕妇（0.4%）检测出戊型肝炎病毒IgM呈阳性，而来自两个研究地点的社区居民戊型肝炎病毒IgM患病率为零。在孕妇中检测到戊型肝炎病毒IgM，尤其是在孕晚期，具有临床和流行病学意义。因此，尼日利亚有必要建立一个强大的戊型肝炎病毒监测系统，特别是在孕妇群体中，以改善母婴健康。
