Silvestre J F, Mercader P, Giménez-Arnau A M
Sección de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
Actas Dermosifiliogr. 2010 Apr;101(3):217-22.
Dimethyl fumarate is a fumaric acid ester. It been used for some years to treat psoriasis and also as a preservative in desiccant sachets in the transport of furniture and footwear. Its irritant properties and sensitizing potential in contact with the skin were recently highlighted when it was implicated as the causative agent in 2 epidemics of severe acute eczema: sofa dermatitis in northern Europe and shoe dermatitis in Spain. The present article aims to guide dermatologists in the diagnosis and management of patients allergic to dimethyl fumarate. We review the clinical manifestations, results of patch tests, possible cross-reactions, and sources of exposure to dimethyl fumarate responsible for these skin reactions.
富马酸二甲酯是一种富马酸酯。多年来它一直被用于治疗牛皮癣，并且在家具和鞋类运输中作为干燥剂小袋中的防腐剂。当它被认为是两起严重急性湿疹流行的致病因素时，其刺激性特性以及与皮肤接触时的致敏潜力最近受到了关注：北欧的沙发皮炎和西班牙的鞋皮炎。本文旨在指导皮肤科医生对富马酸二甲酯过敏患者进行诊断和管理。我们回顾了临床表现、斑贴试验结果、可能的交叉反应以及导致这些皮肤反应的富马酸二甲酯接触源。
