Santiago Felicidade, Andrade Pedro, Gonçalo Margarida, Mascarenhas Rosa, Figueiredo Américo
Dermatology Department, Hospitais da Universidade de Coimbra, Coimbra, Portugal.
Dermatol Online J. 2010 Mar 15;16(3):3.
In the last two years several cases of severe contact dermatitis related to newly acquired sofas and armchairs originating from China have been published. The responsible allergen is dimethylfumarate (DMF), an extremely potent sensitizer and irritant found in sachets inside the furniture. Recently, cases of contact dermatitis related to shoes and riding helmets have also been described.
We evaluated two patients with allergic contact dermatitis related to shoes manufactured in China that were contaminated by dimethylfumarate found in sachets placed inside the shoeboxes.
Patch tests with DMF extracted from the sachets inside the shoeboxes showed positive reactions. Postitive reactions were also obtained using small fragments of the shoes and tissue of the "MouldProof" sachet. The patients were instructed to avoid the suspected shoes and were treated with topical corticosteroids.
Contact dermatitis induced by dimethylfumarate should be suspected in appropriate cases. It is important to remember that this allergen is not included in most series for patch testing.
在过去两年中，已发表了几例与源自中国的新购置沙发和扶手椅相关的严重接触性皮炎病例。致病过敏原是富马酸二甲酯（DMF），一种在家具内小袋中发现的极强致敏剂和刺激物。最近，也有与鞋子和骑行头盔相关的接触性皮炎病例的描述。
我们评估了两名与中国制造的鞋子相关的过敏性接触性皮炎患者，这些鞋子被鞋盒内小袋中发现的富马酸二甲酯污染。
用从鞋盒内小袋中提取的富马酸二甲酯进行斑贴试验显示阳性反应。使用鞋子的小碎片和“防霉”小袋的组织也获得了阳性反应。指导患者避免穿可疑鞋子，并用外用皮质类固醇进行治疗。
在适当的病例中应怀疑由富马酸二甲酯引起的接触性皮炎。重要的是要记住，这种过敏原在大多数斑贴试验系列中未包括。
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