Suntz M, Failing K, Hecht W, Schwartz D, Reinacher M
Institut für Veterinaer-Pathologie, Justus-Liebig-Universitaet Giessen, Frankfurter Strasse 96, 35392 Giessen, Hessen, Germany.
Vet Immunol Immunopathol. 2010 Jul;136(1-2):71-80. doi: 10.1016/j.vetimm.2010.02.014. Epub 2010 Mar 25.
Applying a combination of semi-nested PCR and immunohistology (IHC), the presence of exogenous feline leukemia virus infection was studied in 302 necropsied cats with various disorders. 9% showed the classical outcome of persistent productive FeLV infection which was represented by FeLV antigen expression in different organs. 152 cats (50%) harboured exogenous FeLV-specific proviral sequences in the bone marrow but did not express viral antigen. These cats were considered as horizontally but non-productively infected. Statistical evaluation showed a significant association of non-productive horizontal FeLV infection with a variety of parameters. Non-productively infected cats were statistically significantly older and more often originated from animal shelters than cats without exogenous FeLV infection. Furthermore, some pathological disorders like anemia, panleukopenia, and purulent inflammation showed significant association with non-productive FeLV infection. No significant association was found with lymphosarcoma, known for a long time to be induced by productive FeLV infection.
应用半巢式聚合酶链反应（PCR）和免疫组织化学（IHC）相结合的方法，对302只患有各种疾病的剖检猫进行了外源性猫白血病病毒感染情况的研究。9%的猫表现出持续性增殖性猫白血病病毒感染的典型结果，即不同器官中存在猫白血病病毒抗原表达。152只猫（50%）骨髓中含有外源性猫白血病病毒特异性前病毒序列，但未表达病毒抗原。这些猫被认为是水平感染但无增殖性感染。统计评估显示，无增殖性水平猫白血病病毒感染与多种参数之间存在显著关联。与没有外源性猫白血病病毒感染的猫相比，无增殖性感染的猫在统计学上年龄显著更大，且更多来自动物收容所。此外，一些病理紊乱，如贫血、全白细胞减少和脓性炎症，与无增殖性猫白血病病毒感染存在显著关联。未发现与长期以来已知由增殖性猫白血病病毒感染诱发的淋巴肉瘤有显著关联。
