Medical Microbiology, Department of Laboratory Medicine Malmö, Lund University, Skåne University Hospital, SE-205 02 Malmö, Sweden.
Trends Microbiol. 2010 Jun;18(6):258-65. doi: 10.1016/j.tim.2010.03.007.
The respiratory tract pathogen Haemophilus influenzae is responsible for a variety of infections in humans including septicemia, bronchitis, pneumonia, and acute otitis media. The pathogenesis of H. influenzae relies on its capacity to resist human host defenses including the complement system, and thus H. influenzae has developed several efficient strategies to circumvent complement attack. In addition to attracting specific host complement regulators directly to the bacterial surface, the capsule, lipooligosaccharides, and several outer membrane proteins contribute to resistance against complement-mediated attacks and hence increased bacterial survival. Insights into the mechanisms of complement evasion by H. influenzae are important for understanding pathogenesis and for developing vaccines and new therapies aimed at patients with, for example, chronic obstructive pulmonary disease. Here we overview current knowledge on the different mechanisms by which H. influenzae evades attack by the host complement system.
呼吸道病原体流感嗜血杆菌可引起包括败血症、支气管炎、肺炎和急性中耳炎在内的多种人类感染。流感嗜血杆菌的发病机制依赖于其抵抗包括补体系统在内的人体宿主防御的能力，因此流感嗜血杆菌已发展出几种有效的策略来规避补体攻击。除了直接将特定的宿主补体调节剂吸引到细菌表面外，荚膜、脂寡糖和几种外膜蛋白有助于抵抗补体介导的攻击，从而增加细菌的存活。了解流感嗜血杆菌逃避补体的机制对于理解发病机制以及开发疫苗和针对例如慢性阻塞性肺疾病患者的新疗法非常重要。在这里，我们综述了流感嗜血杆菌逃避宿主补体系统攻击的不同机制的现有知识。
