用于跟踪和干扰唾液酸和岩藻糖单糖表达的化学工具。
Chemical tools to track and perturb the expression of sialic acid and fucose monosaccharides.
机构信息
Department of Synthetic Organic Chemistry, Institute for Molecules and Materials, Radboud University, Heyendaalseweg 135, 6525AJ, Nijmegen, The Netherlands.
出版信息
Chem Commun (Camb). 2022 Nov 1;58(87):12139-12150. doi: 10.1039/d2cc04275d.
The biosynthesis of glycans is a highly conserved biological process and found in all domains of life. The expression of cell surface glycans is increasingly recognized as a target for therapeutic intervention given the role of glycans in major pathologies such as cancer and microbial infection. Herein, we summarize our contributions to the development of unnatural monosaccharide derivatives to infiltrate and alter the expression of both mammalian and bacterial glycans and their therapeutic application.
糖链的生物合成是一种高度保守的生物过程，存在于所有生命领域。鉴于糖链在癌症和微生物感染等主要疾病中的作用，细胞表面糖链的表达越来越被认为是治疗干预的目标。在此，我们总结了我们在开发非天然单糖衍生物以渗透和改变哺乳动物和细菌糖链的表达及其治疗应用方面的贡献。
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