Hashikawa T, Rausell E, Molinari M, Jones E G
Neural Systems Laboratory, Frontier Research Program, RIKEN, Saitama, Japan.
Brain Res. 1991 Mar 29;544(2):335-41. doi: 10.1016/0006-8993(91)90076-8.
Neuronal immunoreactivity for the calcium binding proteins, parvalbumin and calbindin, has been examined immunohistochemically in the monkey medial geniculate complex. Neurons containing one or other of these proteins were present in most (but not all) regions of the complex and were differentially distributed; parvalbumin immunoreactive neurons tended to form densely packed clusters in the ventral nucleus and rather loose arrangements in the anterodorsal and posterodorsal nuclei, whereas most calbindin neurons were scattered, with concentrations in the caudal end of the posterodorsal and in the magnocellular nuclei. In fluorescent tracer experiments combined with immunohistochemistry, it was found that parvalbumin and calbindin neurons project to layer IV and to layer I, respectively, of the primary auditory cortex. These results suggest the presence of parallel and chemically differentiated geniculocortical pathways which make different contributions to the neuronal circuitry of the auditory cortex.
运用免疫组织化学方法，对猴子内侧膝状体复合体中钙结合蛋白小白蛋白和钙结合蛋白的神经元免疫反应性进行了研究。含有其中一种蛋白质的神经元存在于复合体的大多数（但并非全部）区域，且分布各异；小白蛋白免疫反应性神经元往往在腹侧核中形成密集的簇状，在前背侧核和后背侧核中排列较为松散，而大多数钙结合蛋白神经元则呈散在分布，在后背侧核的尾端和大细胞核中有集中分布。在结合免疫组织化学的荧光示踪实验中，发现小白蛋白和钙结合蛋白神经元分别投射到初级听觉皮层的IV层和I层。这些结果表明存在平行且化学性质不同的膝状体皮质通路，它们对听觉皮层的神经元回路有不同的贡献。
