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Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster.泛素和 TSG101 蛋白在中央超分子激活簇的形成和功能中的必需作用。
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Dynein-driven transport of T cell receptor microclusters regulates immune synapse formation and T cell activation.动力蛋白驱动的 T 细胞受体微簇运输调节免疫突触形成和 T 细胞激活。
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Signals and sequences that control CD28 localization to the central region of the immunological synapse.控制CD28定位于免疫突触中心区域的信号和序列。
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Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.免疫突触处 T 细胞受体富集微泡的极化释放。
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The immunological synapse: a cause or consequence of T-cell receptor triggering?免疫突触：T 细胞受体触发的原因还是结果？
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T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.T细胞-树突状细胞免疫突触包含募集蛋白激酶Cθ的TCR依赖性CD28-CD80簇。
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Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.通过TCR-CD28微簇和蛋白激酶Cθ易位对T细胞共刺激的时空调节。
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Protein kinase Ctheta focusing at the cSMAC is a consequence rather than cause of TCR signaling and is dependent on the MEK/ERK pathway.蛋白激酶Cθ聚集于中心超分子激活簇是TCR信号传导的结果而非原因，且依赖于MEK/ERK途径。
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T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster.T细胞受体近端信号在外周微簇中持续存在，并在中央超分子激活簇中终止。
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Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters.通过 TCR 微簇对 T 细胞激活和共刺激的动态调节。
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Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease.免疫突触：结构、分子机制及在疾病中的治疗意义
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Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering.配体诱导与大细胞膜表面磷酸酶的分离是 γδ TCR 触发的关键步骤。
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Self-programmed dynamics of T cell receptor condensation.T 细胞受体凝聚的自我编程动力学。
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The multifaceted interactions between pathogens and host ESCRT machinery.病原体与宿主 ESCRT 机制的多方面相互作用。
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Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4 T cells.TSG101-IFT20 轴调控 CD4 T 细胞中 c-SMAC 的形成和 AKT-mTOR 信号通路。
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Clathrin mediates both internalization and vesicular release of triggered T cell receptor at the immunological synapse.网格蛋白介导触发型 T 细胞受体在免疫突触处的内化和小泡释放。
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Joining Forces for Cancer Treatment: From "TCR versus CAR" to "TCR and CAR".联合力量治疗癌症：从“TCR 与 CAR”到“TCR 和 CAR”。
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Learning from TCR Signaling and Immunological Synapse Assembly to Build New Chimeric Antigen Receptors (CARs).从 TCR 信号和免疫突触组装中学习，以构建新型嵌合抗原受体 (CAR)。
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Lymphocyte Polarization During Immune Synapse Assembly: Centrosomal Actin Joins the Game.免疫突触装配过程中的淋巴细胞极化：中心体肌动蛋白加入游戏。
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本文引用的文献
1
ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane.ESCRT-I 功能对于 Tyrp1 从早期内体向黑素体限膜的运输是必需的。
Traffic. 2009 Sep;10(9):1318-36. doi: 10.1111/j.1600-0854.2009.00955.x. Epub 2009 Jun 9.
2
ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting.内体分选转运复合体（ESCRT）泛素结合结构域在多泡体（MVB）货物分选过程中协同发挥作用。
J Cell Biol. 2009 Apr 20;185(2):213-24. doi: 10.1083/jcb.200811130.
3
Membrane scission by the ESCRT-III complex.ESCRT-III复合物介导的膜分裂
Nature. 2009 Mar 12;458(7235):172-7. doi: 10.1038/nature07836. Epub 2009 Feb 22.
4
Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation.通过TCR-CD28微簇和蛋白激酶Cθ易位对T细胞共刺激的时空调节。
Immunity. 2008 Oct 17;29(4):589-601. doi: 10.1016/j.immuni.2008.08.011. Epub 2008 Oct 9.
5
T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta.T细胞-树突状细胞免疫突触包含募集蛋白激酶Cθ的TCR依赖性CD28-CD80簇。
J Immunol. 2008 Oct 1;181(7):4852-63. doi: 10.4049/jimmunol.181.7.4852.
6
The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.免疫突触中心处T细胞受体信号传导与降解之间的平衡由抗原质量决定。
Immunity. 2008 Sep 19;29(3):414-22. doi: 10.1016/j.immuni.2008.06.014. Epub 2008 Aug 28.
7
T-cell activation through immunological synapses and kinapses.通过免疫突触和动态突触实现T细胞活化。
Immunol Rev. 2008 Feb;221:77-89. doi: 10.1111/j.1600-065X.2008.00589.x.
8
Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells.Jurkat T细胞免疫突触形成过程中T细胞受体和黏附分子分离的机制。
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20296-301. doi: 10.1073/pnas.0710258105. Epub 2007 Dec 12.
9
c-Cbl-mediated regulation of LAT-nucleated signaling complexes.c-Cbl介导的LAT成核信号复合物的调控
Mol Cell Biol. 2007 Dec;27(24):8622-36. doi: 10.1128/MCB.00467-07. Epub 2007 Oct 15.
10
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.人类内体分选转运复合体（ESCRT）和ALIX蛋白与中体蛋白相互作用，并在胞质分裂中发挥作用。
EMBO J. 2007 Oct 3;26(19):4215-27. doi: 10.1038/sj.emboj.7601850. Epub 2007 Sep 13.
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