Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Contraception. 2010 May;81(5):435-40. doi: 10.1016/j.contraception.2010.01.017. Epub 2010 Feb 10.
The study was conducted to test the feasibility of conducting a randomized controlled contraceptive trial in postpartum teens and to assess whether postpartum advanced supply of emergency contraception (EC) to teenaged mothers helps to prevent repeat pregnancies of close proximity.
We performed a randomized controlled trial of 50 postpartum teens at an urban academic medical center. Participants in the intervention arm received routine postpartum contraceptive care and advanced supply of one pack of EC pills with unlimited supply thereafter upon request. The routine care arm (RCA) received routine postpartum contraceptive care. We asked open-ended questions about how we might maximize study retention and implemented the participants' requests in both arms.
Our retention rate was 78%. There were three (13%) pregnancies out of 23 participants in the intervention arm and eight (30%) pregnancies out of 27 participants in the RCA. The risk of pregnancy occurring in the intervention arm was 0.57 times that of the RCA (95% CI 0.20-1.60; p=.23).
A randomized controlled trial of postpartum teens to receive and not to receive advanced supply of EC is both feasible and necessary. Our study provides preliminary data to suggest that advanced supply of EC may help decrease repeat teen pregnancies.
本研究旨在测试在产后青少年中进行随机对照避孕试验的可行性，并评估向未成年母亲提前提供紧急避孕药（EC）是否有助于防止近距离重复怀孕。
我们在一家城市学术医疗中心对 50 名产后青少年进行了一项随机对照试验。干预组的参与者接受常规产后避孕护理，并在需要时提前获得一包 EC 药丸，此后可无限量供应。常规护理组（RCA）接受常规产后避孕护理。我们提出了关于如何最大限度地提高研究保留率的开放式问题，并在两个组中实施了参与者的要求。
我们的保留率为 78%。干预组有 3 名（13%）参与者怀孕，而 RCA 组有 8 名（30%）参与者怀孕。干预组怀孕的风险是 RCA 的 0.57 倍（95%CI 0.20-1.60；p=.23）。
对产后青少年进行接受和不接受提前提供 EC 的随机对照试验是可行且必要的。我们的研究提供了初步数据，表明提前提供 EC 可能有助于减少青少年的重复怀孕。
