Boston University Medical Center, Boston University, Boston, MA 02118, USA.
Contraception. 2010 May;81(5):441-5. doi: 10.1016/j.contraception.2009.12.018. Epub 2010 Feb 1.
We evaluated the efficacy and acceptability of repeat doses of buccal misoprostol compared to vaginal misoprostol for second trimester pregnancy termination by induction.
Women requesting termination of a pregnancy between 18 and 22 weeks gestation were approached for participation. All women received 400 mcg misoprostol vaginally on admission. Participants were randomized to receive subsequent doses of 200 mcg misoprostol every 6 h either buccally or vaginally. All participants completed an acceptability survey.
Sixty-four women participated. The mean gestational age was 19.7 weeks. The median time to abortion in the buccal group was 15 h, which was not significantly different (p=0.44) from the vaginal-only group of 12 h. Most women in both groups preferred their allocated administrative route.
Repeat doses of buccal misoprostol are as effective as vaginal misoprostol in inducing abortions in the midtrimester and are highly acceptable to most women. It is reasonable to offer both options to women.
我们评估了重复使用颊黏膜米索前列醇相对于阴道米索前列醇用于诱导中期妊娠终止的疗效和可接受性。
我们招募了妊娠 18-22 周要求终止妊娠的女性。所有女性在入院时均接受 400 mcg 米索前列醇阴道给药。参与者随机分为两组，分别接受每 6 小时颊黏膜或阴道给予 200 mcg 米索前列醇的后续剂量。所有参与者均完成了一项可接受性调查。
共有 64 名女性参与。平均妊娠龄为 19.7 周。颊黏膜组的流产中位时间为 15 小时，与阴道组的 12 小时相比无显著差异（p=0.44）。两组中大多数女性都更喜欢其分配的给药途径。
重复使用颊黏膜米索前列醇与阴道米索前列醇在诱导中期妊娠流产方面同样有效，并且大多数女性都高度接受。向女性提供这两种选择是合理的。
