用于诱导孕早期和孕中期流产的米索前列醇经口腔与经阴道给药比较
Buccal versus vaginal misoprostol administration for the induction of first and second trimester abortions.
作者信息
Garg Geetika, Takkar Navneet, Sehgal Alka
机构信息
Department of Obstetrics and Gynecology, Government Multispeciality Hospital Sector 16, Chandigarh, India.
Department of Obstetrics and Gynecology, Government Medical College and Hospital, Sector 32, Chandigarh, India.
出版信息
J Obstet Gynaecol India. 2015 Apr;65(2):111-6. doi: 10.1007/s13224-014-0605-5. Epub 2014 Oct 31.
OBJECTIVES
To compare the effectiveness, side effects, and patient satisfaction of buccal versus vaginal misoprostol administration in first and second trimester induced abortions.
METHODS
In first trimester, women received oral mifepristone followed by misoprostol either by buccal or vaginal route. In second trimester, women received oral mifepristone followed by repeated doses of misoprostol either by buccal or vaginal route. A comparative analysis using SPSS was done.
RESULTS
In first trimester, success rate of medical abortion was 96 % in buccal group and 88 % in vaginal group. Nausea was the most common adverse effect which was similar in both groups. In second trimester, success rate was 96 % in buccal group and 80 % in vaginal group. A statistically higher incidence of nausea was noticed in buccal group. Patient satisfaction level was almost similar in both the groups in both trimesters.
CONCLUSIONS
Buccal and vaginal routes of misoprostol administration have similar efficacy and patient satisfaction level for first and second trimester induced abortions. Hence, buccal route may serve as an alternative to vaginal misoprostol.
目的
比较米索前列醇经颊部给药与经阴道给药用于早孕期和中孕期人工流产的有效性、副作用及患者满意度。
方法
早孕期，女性先口服米非司酮，随后米索前列醇经颊部或阴道给药。中孕期，女性先口服米非司酮，随后米索前列醇经颊部或阴道多次给药。使用SPSS进行对比分析。
结果
早孕期，颊部给药组药物流产成功率为96%，阴道给药组为88%。恶心是最常见的不良反应，两组相似。中孕期，颊部给药组成功率为96%，阴道给药组为80%。颊部给药组恶心发生率在统计学上更高。两个孕期两组患者满意度水平几乎相似。
结论
米索前列醇经颊部给药与经阴道给药用于早孕期和中孕期人工流产的疗效及患者满意度水平相似。因此，颊部给药可作为经阴道使用米索前列醇的替代方法。
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