Schussler G C, Orlando J
Science. 1978 Feb 10;199(4329):686-8. doi: 10.1126/science.204004.
Fasting decreases the ratio of hepatic nuclear to serum triiodothyronine (T3) by diminishing the binding capacity of nuclear T3 receptors. In combination with the lower serum T3 concentration caused by fasting, the decrease in receptor content results in a marked decrease in nuclear T3-receptor complexes. The changes in T3 receptor content and circulating T3 in fasted animals appear to be independent synergistic adaptations for caloric conservation in the fasted state. Unlike changes in hormonal level, the modification of nuclear receptor content provides a mechanism that may protect cells with a low caloric reserve independently of the metabolic status of the whole animal.
禁食通过降低肝细胞核甲状腺素（T3）受体的结合能力，减少肝细胞核与血清三碘甲状腺原氨酸（T3）的比率。结合禁食导致的血清T3浓度降低，受体含量的减少会导致细胞核T3-受体复合物显著减少。禁食动物中T3受体含量和循环T3的变化似乎是在禁食状态下节约热量的独立协同适应机制。与激素水平的变化不同，核受体含量的改变提供了一种机制，该机制可以独立于整个动物的代谢状态来保护热量储备低的细胞。
