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Is there a human model for the 'metabolic syndrome' with a defined aetiology?

作者信息

Gorden P, Lupsa B C, Chong A Y, Lungu A O

出版信息

Diabetologia. 2010 Jul;53(7):1534-6. doi: 10.1007/s00125-010-1719-7. Epub 2010 Apr 17.

DOI:10.1007/s00125-010-1719-7
PMID:20401463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3499968/
Abstract
摘要

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Is there a human model for the 'metabolic syndrome' with a defined aetiology?是否存在一种病因明确的“代谢综合征”人体模型？
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[Not Available].[无可用内容]。
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Lipodystrophy Due to Adipose Tissue-Specific Insulin Receptor Knockout Results in Progressive NAFLD.脂肪组织特异性胰岛素受体敲除导致的脂肪营养不良会引发进行性非酒精性脂肪性肝病。
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Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.注射用美曲普汀用于治疗先天性或获得性全身性脂肪营养不良患者的瘦素缺乏并发症。
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Ther Clin Risk Manag. 2015 Sep 16;11:1391-400. doi: 10.2147/TCRM.S66521. eCollection 2015.
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本文引用的文献

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Efficacy of leptin therapy in the different forms of human lipodystrophy.瘦素治疗不同类型人类脂肪营养不良的疗效。
Diabetologia. 2010 Jan;53(1):27-35. doi: 10.1007/s00125-009-1502-9. Epub 2009 Sep 2.
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The metabolic syndrome--a new worldwide definition.代谢综合征——一个新的全球定义。
Lancet. 2005;366(9491):1059-62. doi: 10.1016/S0140-6736(05)67402-8.
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The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes.代谢综合征：进行批判性评估的时候了：美国糖尿病协会和欧洲糖尿病研究协会联合声明
Diabetes Care. 2005 Sep;28(9):2289-304. doi: 10.2337/diacare.28.9.2289.
4
American College of Endocrinology position statement on the insulin resistance syndrome.美国内分泌学会关于胰岛素抵抗综合征的立场声明。
Endocr Pract. 2003 May-Jun;9(3):237-52.
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Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma.由核受体过氧化物酶体增殖物激活受体γ中的显性负性突变导致的人类代谢综合征。
Diabetes. 2003 Apr;52(4):910-7. doi: 10.2337/diabetes.52.4.910.
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Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III).国家胆固醇教育计划（NCEP）成人高血胆固醇检测、评估与治疗专家小组第三次报告（成人治疗小组第三次报告）执行摘要
JAMA. 2001 May 16;285(19):2486-97. doi: 10.1001/jama.285.19.2486.
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Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.重组瘦素用于肥胖和体重正常成年人减肥：一项随机、对照、剂量递增试验。
JAMA. 1999 Oct 27;282(16):1568-75. doi: 10.1001/jama.282.16.1568.
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Comment on the provisional report from the WHO consultation. European Group for the Study of Insulin Resistance (EGIR).对世界卫生组织磋商临时报告的评论。欧洲胰岛素抵抗研究小组（EGIR）。
Diabet Med. 1999 May;16(5):442-3. doi: 10.1046/j.1464-5491.1999.00059.x.
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Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation.糖尿病及其并发症的定义、诊断和分类。第1部分：糖尿病的诊断和分类——世界卫生组织咨询会议临时报告
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Positional cloning of the mouse obese gene and its human homologue.小鼠肥胖基因及其人类同源基因的定位克隆。
Nature. 1994 Dec 1;372(6505):425-32. doi: 10.1038/372425a0.