新型局部麻醉药递送系统对手臂皮肤血流反应性的影响。

The effect of a new topical local anaesthetic delivery system on forearm skin blood flow reactivity.

机构信息

University Department of Anaesthesia, University of Nottingham, Nottingham, UK.

出版信息

Anaesthesia. 2010 Feb;65(2):178-83. doi: 10.1111/j.1365-2044.2009.06192.x.

DOI:10.1111/j.1365-2044.2009.06192.x

PMID:20402845

Abstract

Different topical local anaesthetics have varying effects on skin blood flow and vascular reactivity. We compared the vasoactive properties of Rapydan, a new topical local anaesthetic, with those of Ametop and EMLA creams in 20 healthy volunteers. Blood flow and vascular reactivity in the forearm skin were assessed by laser Doppler flowmetry and the transient hyperaemic response ratio respectively, before and after the application of EMLA (for 60 min), Ametop (for 30 and 60 min) and Rapydan (for 30 min). Application of EMLA had no effect on skin blood flow (median (IQR [range]) change from baseline -0.9% (-63 to 414 [-38.5 to 51.3] %, p = 1.0)) or mean (SD) transient hyperaemic response ratio (from 2.86 (0.86) to 3.17 (1.3), p = 0.38). The application of Ametop for 60 min produced a greater median (IQR [range]) increase in blood flow from baseline (508 (-55 to 998 [148-649]) %) than Rapydan applied for 30 min 160 (-77 to 997 [45-301]) %, p = 0.001), and a similar decrease in mean (SD) transient hyperaemic response ratio (from 2.69 (1.16) to 1.08 (0.26) and from 2.83 (0.84) to 1.49 (0.93) respectively, p = 0.57).

摘要

不同的局部表面麻醉剂对皮肤血流和血管反应性有不同的影响。我们在 20 名健康志愿者中比较了新型局部麻醉剂 Rapydan 与 Ametop 和 EMLA 乳膏的血管活性特性。应用 EMLA（60 分钟）、Ametop（30 和 60 分钟）和 Rapydan（30 分钟）前后，分别通过激光多普勒血流仪和瞬时充血反应比评估前臂皮肤的血流和血管反应性。应用 EMLA 对皮肤血流（从基线的中位数（IQR [范围]）变化 -0.9%（-63 至 414 [-38.5 至 51.3]%，p=1.0）或平均（SD）瞬时充血反应比（从 2.86（0.86）到 3.17（1.3），p=0.38）无影响。应用 Ametop 60 分钟与 Rapydan 30 分钟相比，从基线的中位数（IQR [范围]）增加了更多的血流（508（-55 至 998 [148-649]%）比 160（-77 至 997 [45-301]%），p=0.001），平均（SD）瞬时充血反应比也有类似的下降（从 2.69（1.16）到 1.08（0.26）和从 2.83（0.84）到 1.49（0.93），分别，p=0.57）。