Toll 样受体 4 在中枢神经系统疾病中的作用。
Toll-like receptor 4 in CNS pathologies.
机构信息
Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, Colorado 80309-0215, USA.
出版信息
J Neurochem. 2010 Jul;114(1):13-27. doi: 10.1111/j.1471-4159.2010.06736.x. Epub 2010 Apr 6.
Abstract
The responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.
摘要
大脑对感染、缺血和创伤的反应具有显著的相似性。中枢神经系统的这些和其他情况协调先天免疫反应，其特征是小胶质细胞（神经系统中的巨噬样细胞）的激活。小胶质细胞激活的一个重要贡献者是 Toll 样受体 4，这是一种病原体相关分子模式受体，已知它会在各种中枢神经系统刺激下引发炎症级联反应。本综述追溯了在神经系统炎症病因学中表征和控制 Toll 样受体 4 的新努力。
相似文献
1
Toll-like receptor 4 in CNS pathologies. Toll 样受体 4 在中枢神经系统疾病中的作用。
J Neurochem. 2010 Jul;114(1):13-27. doi: 10.1111/j.1471-4159.2010.06736.x. Epub 2010 Apr 6.
2
CD14 is a key organizer of microglial responses to CNS infection and injury.CD14 是小胶质细胞对中枢神经系统感染和损伤反应的关键调节者。
Glia. 2016 Apr;64(4):635-49. doi: 10.1002/glia.22955. Epub 2015 Dec 18.
3
The innate immunity of the central nervous system in chronic pain: the role of Toll-like receptors.慢性疼痛中中枢神经系统的固有免疫：Toll样受体的作用
Cell Mol Life Sci. 2007 May;64(9):1128-36. doi: 10.1007/s00018-007-6494-3.
4
Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury.先天免疫和中枢神经系统中的神经炎症：小胶质细胞在 Toll 样受体介导的神经元损伤中的作用。
Glia. 2010 Feb;58(3):253-63. doi: 10.1002/glia.20928.
5
Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders.靶向 Toll 样受体 4 调节中枢神经系统疾病中的神经炎症。
Expert Opin Ther Targets. 2019 Oct;23(10):865-882. doi: 10.1080/14728222.2019.1676416. Epub 2019 Oct 20.
6
Modulation of the Endocannabinoid System Following Central Nervous System Injury.中枢神经系统损伤后内源性大麻素系统的调制。
Int J Mol Sci. 2019 Jan 17;20(2):388. doi: 10.3390/ijms20020388.
7
Metabolic Control of Microglia.代谢控制小胶质细胞。
Adv Neurobiol. 2024;37:607-622. doi: 10.1007/978-3-031-55529-9_34.
8
Pattern recognition receptors and central nervous system repair.模式识别受体与中枢神经系统修复
Exp Neurol. 2014 Aug;258:5-16. doi: 10.1016/j.expneurol.2014.01.001.
9
Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases.星型胶质细胞 toll 样受体（TLRs）在中枢神经系统感染、损伤和神经退行性疾病中的作用。
Brain Behav Immun. 2021 Jan;91:740-755. doi: 10.1016/j.bbi.2020.10.007. Epub 2020 Oct 8.
10
Toll-like receptors in inflammation of the central nervous system. Toll 样受体在中枢神经系统炎症中的作用。
Int Immunopharmacol. 2011 Oct;11(10):1407-14. doi: 10.1016/j.intimp.2011.04.025. Epub 2011 May 18.
引用本文的文献
1
A Novel HDAC6 Inhibitor Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice.一种新型组蛋白去乙酰化酶6抑制剂可改善咪喹莫特诱导的小鼠银屑病样炎症。
Molecules. 2025 Jul 31;30(15):3224. doi: 10.3390/molecules30153224.
2
Therapeutic potential of calcitriol in cerebral ischemia/reperfusion injury: In vivo and in silico insights into TLR4 and FGFR2 pathways.骨化三醇在脑缺血/再灌注损伤中的治疗潜力：对TLR4和FGFR2通路的体内及计算机模拟研究
IBRO Neurosci Rep. 2025 Jul 29;19:345-353. doi: 10.1016/j.ibneur.2025.06.018. eCollection 2025 Dec.
3
The Role of Myeloid Differentiation Factor 2 in Stroke: Mechanisms and Therapeutic Potential.髓样分化因子2在中风中的作用：机制与治疗潜力
Biomolecules. 2025 Jul 4;15(7):961. doi: 10.3390/biom15070961.
4
From receptor to response: dissecting the TLR4 pathway in diabetic neuropathy.从受体到反应：剖析糖尿病神经病变中的TLR4信号通路
Inflammopharmacology. 2025 May 10. doi: 10.1007/s10787-025-01774-2.
5
( +)-Catechin Alleviates CCI-Induced Neuropathic Pain by Modulating Microglia M1 and M2 Polarization via the TLR4/MyD88/NF-κB Signaling Pathway.（+）-儿茶素通过TLR4/MyD88/NF-κB信号通路调节小胶质细胞M1和M2极化减轻CCI诱导的神经性疼痛。
J Neuroimmune Pharmacol. 2025 Apr 7;20(1):33. doi: 10.1007/s11481-025-10202-9.
6
Inflammatory changes in the choroid plexus following subarachnoid hemorrhage: the role of innate immune receptors and inflammatory molecules.蛛网膜下腔出血后脉络丛的炎症变化：固有免疫受体和炎症分子的作用
Front Cell Neurosci. 2025 Jan 7;18:1525415. doi: 10.3389/fncel.2024.1525415. eCollection 2024.
7
Complement Molecule C3a Exacerbates Early Brain Injury After Subarachnoid Hemorrhage by Inducing Neuroinflammation Through the C3aR-ERK-P2X7-NLRP3 Inflammasome Signaling Axis.补体分子C3a通过C3aR-ERK-P2X7-NLRP3炎性小体信号轴诱导神经炎症，加重蛛网膜下腔出血后的早期脑损伤。
Inflammation. 2024 Nov 11. doi: 10.1007/s10753-024-02155-7.
8
Blocking Brain Myeloid Differentiation Factor 2-Toll-like Receptor 4 Signaling Improves Cognition by Diminishing Brain Pathologies and Preserving Adult Hippocampal Neurogenesis in Obese Rats.阻断脑髓系分化因子 2- Toll 样受体 4 信号通路可改善肥胖大鼠认知功能，减少脑部病变，维持成年海马神经发生。
J Neuroimmune Pharmacol. 2024 Oct 7;19(1):51. doi: 10.1007/s11481-024-10151-9.
9
Therapeutic Correlation of TLR-4 Mediated NF-κB Inflammatory Pathways in Ischemic Injuries.TLR-4 介导的 NF-κB 炎症通路在缺血性损伤中的治疗相关性。
Curr Drug Targets. 2024;25(15):1027-1040. doi: 10.2174/0113894501322228240830063605.
10
Perihematomal Neurovascular Protection: Blocking HSP90 Reduces Blood Infiltration Associated with Inflammatory Effects Following Intracerebral Hemorrhage in Rates.血肿周围神经血管保护：阻断热休克蛋白90可减少大鼠脑出血后与炎症效应相关的血液渗入。
Transl Stroke Res. 2024 Sep 4. doi: 10.1007/s12975-024-01289-y.
本文引用的文献
1
Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.热休克蛋白 90 在大鼠 Toll 样受体 4 介导的痛觉增强中的作用证据。
Neuroscience. 2009 Dec 29;164(4):1821-32. doi: 10.1016/j.neuroscience.2009.09.046. Epub 2009 Sep 27.
2
Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain.小胶质细胞 CD40 在神经病理性疼痛小鼠模型中机械性痛觉过敏维持中的关键作用。
Eur J Immunol. 2009 Dec;39(12):3562-9. doi: 10.1002/eji.200939657.
3
Evidence that opioids may have toll-like receptor 4 and MD-2 effects.有证据表明阿片类药物可能具有 Toll 样受体 4 和 MD-2 的作用。
Brain Behav Immun. 2010 Jan;24(1):83-95. doi: 10.1016/j.bbi.2009.08.004. Epub 2009 Aug 11.
4
Extracellular mutant SOD1 induces microglial-mediated motoneuron injury.细胞外突变型 SOD1 诱导小胶质细胞介导的运动神经元损伤。
Glia. 2010 Jan 15;58(2):231-43. doi: 10.1002/glia.20919.
5
Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3.全身脂多糖通过重新编程大脑对中风的反应来保护大脑免受缺血性损伤：IRF3的关键作用。
J Neurosci. 2009 Aug 5;29(31):9839-49. doi: 10.1523/JNEUROSCI.2496-09.2009.
6
Surfactant lipids regulate LPS-induced interleukin-8 production in A549 lung epithelial cells by inhibiting translocation of TLR4 into lipid raft domains.表面活性剂脂质通过抑制 TLR4 向脂筏域的易位来调节 LPS 诱导的 A549 肺上皮细胞中白细胞介素-8 的产生。
J Lipid Res. 2010 Feb;51(2):334-44. doi: 10.1194/jlr.M000513. Epub 2009 Aug 1.
7
Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner.脂肪酸通过以活性氧依赖性方式调节受体二聚化和募集到脂筏中来调节Toll样受体4的激活。
J Biol Chem. 2009 Oct 2;284(40):27384-92. doi: 10.1074/jbc.M109.044065. Epub 2009 Aug 1.
8
NF-kappaB dimers in the regulation of neuronal survival.NF-κB二聚体在神经元存活调节中的作用
Int Rev Neurobiol. 2009;85:351-62. doi: 10.1016/S0074-7742(09)85024-1.
9
Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model.新型小分子 TLR4 信号转导抑制剂 TAK-242 的结合部位分析及其对脓毒症小鼠模型的治疗效果。
Br J Pharmacol. 2009 Aug;157(7):1250-62. doi: 10.1111/j.1476-5381.2009.00297.x. Epub 2009 Jun 25.
10
Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease.腱生蛋白-C是Toll样受体4的内源性激活剂，对维持关节炎性关节疾病中的炎症至关重要。
Nat Med. 2009 Jul;15(7):774-80. doi: 10.1038/nm.1987. Epub 2009 Jun 28.
Zotero 插件