代谢控制小胶质细胞。

Metabolic Control of Microglia.

机构信息

Department of Clinical Neurosciences and NIHR Biomedical Research Centre, University of Cambridge, Cambridge, UK.

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

出版信息

Adv Neurobiol. 2024;37:607-622. doi: 10.1007/978-3-031-55529-9_34.

DOI:10.1007/978-3-031-55529-9_34

PMID:39207716

Abstract

Microglia, immune sentinels of the central nervous system (CNS), play a critical role in maintaining its health and integrity. This chapter delves into the concept of immunometabolism, exploring how microglial metabolism shapes their diverse immune functions. It examines the impact of cell metabolism on microglia during various CNS states, including homeostasis, development, aging, and inflammation. Particularly in CNS inflammation, the chapter discusses how metabolic rewiring in microglia can initiate, resolve, or perpetuate inflammatory responses. The potential of targeting microglial metabolism as a therapeutic strategy for chronic CNS disorders with prominent innate immune cell activation is also explored.

摘要

小胶质细胞是中枢神经系统 (CNS) 的免疫哨兵，在维持其健康和完整方面发挥着关键作用。本章深入探讨了免疫代谢的概念，研究了小胶质细胞代谢如何塑造它们多样化的免疫功能。它检查了细胞代谢对各种 CNS 状态下小胶质细胞的影响，包括内稳态、发育、衰老和炎症。特别是在 CNS 炎症中，本章讨论了小胶质细胞代谢的重编程如何引发、解决或维持炎症反应。还探讨了将小胶质细胞代谢作为一种治疗策略的潜力，用于治疗以固有免疫细胞激活为特征的慢性 CNS 疾病。