Periodontol 2000. 2010 Jun;53:154-66. doi: 10.1111/j.1600-0757.2009.00334.x.
Patients with aggressive periodontitis can be both rewarding and frustrating to treat in clinical practice. Interindividual variation in response to therapy can be widespread, and we do not clearly understand the reasons for this variable response. It is possible that new research into the resolution of inflammation may reveal basic differences between patients with chronic periodontitis and those with aggressive disease. In addition, future research involving modulation of host inflammatory responses may clarify the reasons for the differences in clinical outcomes between patients. We think it likely that this research could result in further alterations to the classification of periodontal diseases, as with more knowledge of the mechanisms of disease it is possible that patients currently classified as having aggressive periodontitis may be found not to represent a single diagnostic entity. Better understanding of the true nature of patients currently identified as having aggressive periodontitis may therefore lead to more effective treatment approaches.
临床上，治疗侵袭性牙周炎患者既有收获也有挫折。治疗反应的个体间差异可能非常广泛，我们也不清楚这种可变反应的原因。新的炎症消退研究可能揭示慢性牙周炎患者和侵袭性疾病患者之间的基本差异。此外，涉及宿主炎症反应调节的未来研究可能阐明患者之间临床结果差异的原因。我们认为，这项研究可能导致牙周病分类的进一步改变，随着对疾病机制的更多了解，目前被归类为侵袭性牙周炎的患者可能不代表单一的诊断实体。因此，更好地了解目前被确定为侵袭性牙周炎患者的真实性质可能会导致更有效的治疗方法。
