Yamada S, Yokoo H, Harajiri S, Nishi S
Institute of Brain Diseases, Kurume University School of Medicine, Japan.
Eur J Pharmacol. 1991 Jan 3;192(1):141-5. doi: 10.1016/0014-2999(91)90080-a.
The effects of chronic treatment with haloperidol on spontaneous and electrically evoked dopamine (DA) release from striatal slices of rats were investigated in vitro. DA was measured by high-performance liquid chromatography coupled to an electrochemical detector. The superfusion with haloperidol caused a dose-dependent (100 nM-100 microM) reduction in the electrically evoked DA release from striatal slices of rats, which was not antagonized by the superfusion with apomorphine. Chronic administration of haloperidol (1 mg/kg per day for 21 days) caused a significant reduction in electrically evoked DA release as well as in spontaneous DA release from striatal slices 24 h after the last injection. Moreover, pretreatment with haloperidol prevented the reduction of the DA release evoked in response to haloperidol superfusion (1 microM). These results indicated that chronic administration of haloperidol reduced DA release from striatal slices of rats, accompanied by tolerance for the inhibitory effect of drug superfusion on evoked DA release.
在体外研究了氟哌啶醇长期治疗对大鼠纹状体切片中自发和电诱发多巴胺（DA）释放的影响。采用高效液相色谱-电化学检测法测定多巴胺。用氟哌啶醇灌流导致大鼠纹状体切片电诱发的多巴胺释放呈剂量依赖性（100 nM - 100 μM）减少，阿扑吗啡灌流不能拮抗这种作用。长期给予氟哌啶醇（每天1 mg/kg，共21天）导致末次注射后24小时，纹状体切片电诱发的多巴胺释放以及自发多巴胺释放显著减少。此外，用氟哌啶醇预处理可防止因氟哌啶醇灌流（1 μM）引起的多巴胺释放减少。这些结果表明，长期给予氟哌啶醇可减少大鼠纹状体切片中的多巴胺释放，同时伴有对药物灌流抑制诱发多巴胺释放作用的耐受性。
