Department of Chemistry, Karnatak University, Dharwad 580 003, Karnataka, India.
Eur J Med Chem. 2010 Jul;45(7):2981-6. doi: 10.1016/j.ejmech.2010.03.025. Epub 2010 Mar 25.
A new hexadentate macroacyclic N(2)O(4) - donor ligand, glyoxal bis(N-nitroso phenylglycine) (gbnp), has been designed and structurally characterized. Manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of gbnp have been prepared and characterized by elemental analyses, molar conductance measurements, magnetic moment, spectral (IR, (1)H NMR, electronic and FAB mass) and thermal studies. The molecular dynamics of the ligand was studied by the variable temperature NMR studies, which suggest the presence of two isomeric forms. The antimicrobial activity of all the compounds was studied against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Candida albicans. Among the new complexes, copper(II) complex has the highest potential against all the microorganisms tested.
一种新的六齿大环 N(2)O(4) - 给体配体，乙二醛双（N-亚硝基苯甘氨酸）（gbnp），已被设计和结构表征。gbnp 的锰（II）、钴（II）、镍（II）、铜（II）和锌（II）配合物已通过元素分析、摩尔电导率测量、磁矩、光谱（IR、（1）H NMR、电子和 FAB 质谱）和热研究来制备和表征。配体的分子动力学通过变温 NMR 研究进行了研究，这表明存在两种互变异构形式。所有化合物的抗菌活性均针对大肠杆菌、Cirroflagellosus 芽孢杆菌、黑曲霉和白色念珠菌进行了研究。在新的配合物中，铜（II）配合物对所有测试的微生物具有最高的潜力。
