PG Department of Chemistry, Karnatak University, Pawate Nagar, Karnataka, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2010 Jan;75(1):347-54. doi: 10.1016/j.saa.2009.10.039. Epub 2009 Nov 5.
A series of Co(II), Ni(II) and Cu(II) complexes of the type ML(2) have been synthesized with Schiff bases derived from methylthiosemicarbazone and 5-formyl-6-hydroxy coumarin/8-formyl-7-Hydroxy-4-methylcoumarin. The complexes are insoluble in common organic solvents but soluble in DMF and DMSO. The measured molar conductance values in DMF indicate that, the complexes are non-electrolytes in nature. In view of analytical, spectral (IR, UV-vis, ESR, FAB-mass and fluorescence), magnetic and thermal studies, it has been concluded that, all the metal complexes possess octahedral geometry in which ligand is coordinated to metal ion through azomethine nitrogen, thione sulphur and phenolic oxygen atom via deprotonation. The redox behavior of the metal complexes was investigated by using cyclic voltammetry. The Schiff bases and their complexes have been screened for their antibacterial (Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Salmonella typhi) and antifungal activities (Aspergillus niger, Aspergillus flavus and Cladosporium) by Minimum Inhibitory Concentration method. The DNA cleavage is studied by agarose gel electrophoresis method.
已合成了一系列 Co(II)、Ni(II) 和 Cu(II) 配合物，其类型为 ML(2)，配体是由甲基硫代缩氨基脲和 5-甲酰基-6-羟基香豆素/8-甲酰基-7-羟基-4-甲基香豆素衍生而来。这些配合物不溶于常见有机溶剂，但溶于 DMF 和 DMSO。在 DMF 中测量的摩尔电导率值表明，这些配合物本质上是非电解质。鉴于分析、光谱（IR、UV-vis、ESR、FAB-质谱和荧光）、磁性和热研究，得出所有金属配合物都具有八面体几何形状，其中配体通过亚胺氮、硫酮硫和酚氧原子通过去质子化与金属离子配位。通过循环伏安法研究了金属配合物的氧化还原行为。通过最低抑菌浓度法研究了席夫碱及其配合物的抗菌（大肠杆菌、金黄色葡萄球菌、铜绿假单胞菌和伤寒沙门氏菌）和抗真菌活性（黑曲霉、黄曲霉和枝孢菌）。通过琼脂糖凝胶电泳法研究 DNA 切割。
