以吡咯并喹啉模板为基础对 C-2 进行修饰，旨在开发具有更高水溶性的高效疱疹病毒抗病毒药物。
Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals with improved aqueous solubility.
机构信息
Global Research and Development, Pfizer, Inc., Kalamazoo, MI 49007, USA.
出版信息
Bioorg Med Chem Lett. 2010 May 15;20(10):3039-42. doi: 10.1016/j.bmcl.2010.03.115. Epub 2010 Apr 3.
PMID:20403696
Abstract
A series of C-2 pyrroloquinoline analogs designed to improve aqueous solubility were examined for herpesvirus polymerase and antiviral activity. Several analogs were identified that maintained the antiviral activity of the previous development candidate against HCMV, HSV-1 and VZV, but with significantly improved aqueous solubility.
摘要
为了提高水溶性，设计了一系列 C-2 吡咯并喹啉类似物，并对其疱疹病毒聚合酶和抗病毒活性进行了研究。鉴定出几种类似物，它们保持了先前开发候选药物对 HCMV、HSV-1 和 VZV 的抗病毒活性，但水溶性有了显著提高。
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