Kannangai R, Nair S C, Sridharan G, Prasannakumar S, Daniel D
Department of Immunohaematology and Transfusion Medicine, Christian Medical College, Vellore - 632 004, India.
Indian J Med Microbiol. 2010 Apr-Jun;28(2):111-3. doi: 10.4103/0255-0857.62485.
In India, HIV-2 epidemic is alongside with HIV-1. Blood banks are introducing nucleic acid testing (NAT) for screening. The limitation of NAT systems is the inability to detect HIV-2.
An analysis of HIV screening of a blood bank at a tertiary care center from 1998 to 2007 was carried out.
A total of 175026 donors were screened by serological assays and 789 were reactive for HIV antibody. Only 478 (61%) were confirmed positive by Western blot/immunoblot. There were 465 (97.2%) donations positive for HIV-1, 6 (1.3%) for HIV-2 (monotypic infection) and 7 (1.5%) for HIV-1 and HIV-2 (dual infection).
We show the presence of HIV-2 infection among the blood donors and the need for incorporating HIV-2 detection also in the NAT systems.
在印度，HIV-2流行与HIV-1并存。血库正在引入核酸检测（NAT）进行筛查。NAT系统的局限性在于无法检测HIV-2。
对一家三级护理中心血库1998年至2007年的HIV筛查进行了分析。
通过血清学检测共筛查了175026名献血者，789人HIV抗体呈反应性。仅478人（61%）经免疫印迹法确认阳性。HIV-1阳性的献血有465份（97.2%），HIV-2阳性的有6份（1.3%）（单一感染），HIV-1和HIV-2阳性的有7份（1.5%）（双重感染）。
我们发现献血者中存在HIV-2感染，并且在NAT系统中也需要纳入HIV-2检测。
