Newman S P
Department of Thoracic Medicine, Royal Free Hospital and School of Medicine, London, England.
Allergy Proc. 1991 Jan-Feb;12(1):41-5. doi: 10.2500/108854191778879601.
The percentage of the dose reaching the lungs from a pressurized metered dose inhaler (MDI) is likely to be a major determinant of the efficacy of inhaled bronchodilators and corticosteroids. Yet MDIs may deposit no drug in the lungs in patients with poor inhaler technique and no more than 20% of the dose under optimum conditions. Spacer devices can help to deposit as much drug as from a correctly used MDI (even in patients with poor technique) but are often large and bulky. More compact (and easier to use) pressurized devices and multidose dry powder inhalers will be valuable additions to the range of apparatus available for asthma therapy and prophylaxis.
来自定量压力吸入器（MDI）到达肺部的药物剂量百分比可能是吸入性支气管扩张剂和皮质类固醇疗效的主要决定因素。然而，对于吸入技术不佳的患者，MDI可能不会在肺部沉积任何药物，在最佳条件下也不会超过20%的剂量。储雾罐装置可以帮助沉积与正确使用MDI时一样多的药物（即使是技术不佳的患者），但通常体积大且笨重。更紧凑（且更易于使用）的压力装置和多剂量干粉吸入器将是哮喘治疗和预防可用器械范围的有价值补充。
