Caputo Salvatore, Sorice Nunziatina, Sansone Renato, Simeone Domenico, Caruso Vincenzo, Russo Rocco, Cicchella Nicola, Izzo Annamaria, Saviano Carmen, Casani Antonella, Ciampi Quirino, Villari Bruno
aDivision of Cardiology, Fatebenefratelli Hospital bPediatric Practitioner, Benevento, Italy.
J Cardiovasc Med (Hagerstown). 2017 May;18(5):378-380. doi: 10.2459/JCM.0b013e328336b5b7.
A congenital coronary artery fistula (CAF) is a rare form of heart disease in which a coronary artery and a cardiac chamber or another vascular structure communicate. CAF could worsen ventricular perfusion and function, favoring ventricular ischemia and arrhythmias. To our knowledge, this is the first report of CAF, draining in the pulmonary artery, in two asymptomatic dizygotic twin brothers, diagnosed by echocardiography. Dizygotic twins are siblings with different genes exposed to the same environmental experience during the pregnancy. The occurrence of CAF (with similar instrumental findings) in both twin brothers could depend on a poorly identified environmental factor during pregnancy.
先天性冠状动脉瘘（CAF）是一种罕见的心脏病，其特征为冠状动脉与心腔或其他血管结构之间存在异常连通。CAF会使心室灌注和功能恶化，增加心室缺血和心律失常的风险。据我们所知，这是首例通过超声心动图诊断出的、两名无症状的异卵双胞胎兄弟均患有引流至肺动脉的CAF的报告。异卵双胞胎是指在孕期具有不同基因但暴露于相同环境的兄弟姐妹。两名双胞胎兄弟均出现CAF（伴有相似的影像学表现）可能取决于孕期一个尚未明确的环境因素。
