Köhrle J, Brabant G
Institut für Experimentelle Endokrinologie und Endokrinologisches Forschungs-Centrum Charité (EnForCé), Charité - Universitätsmedizin Berlin, CVK, Augustenburger Platz 1, 13353, Berlin, Deutschland.
Internist (Berl). 2010 May;51(5):559-60, 562-7. doi: 10.1007/s00108-009-2494-8.
Understanding of biosynthesis and metabolism of thyroid hormones have recently been substantially improved via the molecular characterization of key players like proteins essential for hormone biosynthesis, cellular thyroid hormone transporters, and intracellular enzymes involved in their activation in peripheral tissues. This improved our understanding of a number of difficult to interpret laboratory conditions. It further stimulated the development of new techniques for the future sensitive and specific measurement of a much wider than the conventional range of secretory products of the thyroid and their organ specific activation.
最近，通过对关键参与者进行分子表征，如激素生物合成所必需的蛋白质、细胞甲状腺激素转运蛋白以及参与外周组织中甲状腺激素激活的细胞内酶，人们对甲状腺激素的生物合成和代谢有了显著的认识提升。这增进了我们对一些难以解释的实验室情况的理解。它还进一步推动了新技术的发展，以便未来能更灵敏、更特异且比传统范围更广地测量甲状腺分泌产物及其器官特异性激活情况。
