Yu Jeong Jin, Choi Hyung Soon, Kim Yong Beom, Son Jae Sung, Kim Young-Hwue, Ko Jae-Kon, Park In-Sook
Division of Pediatric Cardiology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, South Korea.
Pediatr Cardiol. 2010 Aug;31(6):807-12. doi: 10.1007/s00246-010-9708-7. Epub 2010 Apr 20.
This study aimed to investigate left ventricular myocardial deformation in children with Kawasaki disease during the acute phase of their illness. A total of 50 patients and 35 normal control subjects were assessed. Data were obtained from the patients during the acute and convalescent phases of Kawasaki disease. Analyses of myocardial deformation [strain (epsilon), strain rate (SR)] was performed using two-dimensional speckle-tracking imaging in three directions (longitudinal, circumferential, and radial) at the basal and mid levels of the left ventricular myocardium. Basal longitudinal epsilon (P < 0.001) and midlongitudinal epsilon (P < 0.0001) were lower during the acute phase of the disease than in the control subjects and associated with serum albumin level and left ventricular mass index (LVMI). Midlongitudinal SR (P < 0.0001) was lower during the acute phase of Kawasaki disease than in the control subjects and associated with LVMI. Decreased systolic SR was not detected in any direction. In conclusion, left ventricular longitudinal systolic epsilon was significantly decreased during the acute phase of Kawasaki disease. This may be a result of myocardial swelling from myocarditis during the acute phase of the disease.
本研究旨在调查川崎病患儿急性期的左心室心肌变形情况。共评估了50例患者和35名正常对照者。数据取自川崎病患者的急性期和恢复期。使用二维斑点追踪成像在左心室心肌基底和中间水平的三个方向（纵向、圆周和径向）进行心肌变形分析[应变（ε）、应变率（SR）]。疾病急性期的基底纵向ε（P<0.001）和中间纵向ε（P<0.0001）低于对照者，且与血清白蛋白水平和左心室质量指数（LVMI）相关。川崎病急性期的中间纵向SR（P<0.0001）低于对照者，且与LVMI相关。在任何方向均未检测到收缩期SR降低。总之，川崎病急性期左心室纵向收缩期ε显著降低。这可能是疾病急性期心肌炎导致心肌肿胀的结果。
