用于未活化的烷基氯交叉偶联的空气稳定的二级膦氧化物或氯化物（Pre）配体。
Air-stable secondary phosphine oxide or chloride (Pre)ligands for cross-couplings of unactivated alkyl chlorides.
机构信息
Institut für Organische und Biomolekulare Chemie, Georg-August-Universitaet, Tammannstrasse 2, 37077 Goettingen, Germany.
出版信息
Org Lett. 2010 May 21;12(10):2298-301. doi: 10.1021/ol100658y.
PMID:20405884
Abstract
In situ generated and crystallographically well-defined, isolated palladium complexes derived from seven novel air-stable secondary phosphine oxides or chlorides enabled challenging Kumada-Corriu cross-couplings of unactivated alkyl chlorides bearing beta-hydrogens and proved applicable to transformations of alkyl-substituted organometallics.
摘要
从七种新型空气稳定的次膦氧化物或氯化物原位生成并结晶良好的孤立钯配合物，能够实现具有β-氢的未活化烷基氯的挑战性 Kumada-Corriu 交叉偶联，并证明适用于烷基取代的有机金属的转化。
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