Department of Cardiology, Isala Klinieken, Locatie Weezenlanden, Zwolle, the Netherlands.
J Am Geriatr Soc. 2010 May;58(5):867-72. doi: 10.1111/j.1532-5415.2010.02821.x. Epub 2010 Apr 14.
To assess the influence of age as an independent factor determining the prognosis and outcome of patients with acute myocardial infarction (AMI) treated using primary percutaneous coronary intervention (PCI).
A retrospective analysis from a dedicated database.
A high-volume interventional cardiology center in the Netherlands.
Four thousand nine hundred thirty-three consecutive patients with AMI.
Baseline characteristics and clinical outcomes after 30 days and 1 year were compared according to age categorized in three groups: younger than 65, 65 to 74, and 75 and older. A more-detailed analysis was performed with six age groups, from younger than 40 to 80 and older.
Of the 4,933 consecutive patients with AMI treated with PCI between 1992 and 2004, 643 were aged 75 and older. Multivariate analysis revealed that patients aged 65 to 75 had a greater risk of 1-year mortality than those younger than 65 (adjusted odds ratio (AOR)=1.57, 95% confidence interval (CI)=1.15-2.16) and that those aged 75 and older had a greater risk of 1-year mortality than those younger than 65 (AOR=3.03, 95% CI=2.14-4.29).
In this retrospective analysis, older age was independently associated with greater mortality after PCI for AMI. Patients aged 65 and older had a higher risk of mortality than younger patients, and those aged 75 and older had the highest risk of mortality.
评估年龄作为一个独立因素对接受直接经皮冠状动脉介入治疗（PCI）的急性心肌梗死（AMI）患者预后和结局的影响。
来自专用数据库的回顾性分析。
荷兰一家大容量介入心脏病学中心。
4933 例连续 AMI 患者。
根据年龄分为三组（<65 岁、65-74 岁和≥75 岁）比较 30 天和 1 年时的基线特征和临床结局。对六个年龄组（<40 岁、40-49 岁、50-59 岁、60-69 岁、70-79 岁和≥80 岁）进行更详细的分析。
在 1992 年至 2004 年接受 PCI 治疗的 4933 例连续 AMI 患者中，643 例年龄≥75 岁。多变量分析显示，65-74 岁患者 1 年死亡率的风险高于<65 岁患者（校正比值比（AOR）=1.57，95%置信区间（CI）=1.15-2.16），而≥75 岁患者的 1 年死亡率风险高于<65 岁患者（AOR=3.03，95% CI=2.14-4.29）。
在这项回顾性分析中，年龄较大与 PCI 治疗 AMI 后死亡率增加独立相关。65 岁及以上患者的死亡率风险高于年轻患者，而 75 岁及以上患者的死亡率风险最高。
