Arteaga A, Dhand N K, McCann T, Knottenbelt C M, Tebb A J, Evans H, Eckersall P David, Ramsey I K
Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK.
J Small Anim Pract. 2010 Apr;51(4):204-9. doi: 10.1111/j.1748-5827.2009.00863.x.
Acute phase proteins (APPS) include haptoglobin (Hp), C-reactive protein (CRP) and serum amyloid A (SAA). Increased Hp concentrations may be induced by endogenous or exogenous glucocorticoids in dogs.
To assess whether control of hyperadrenocorticism (HAC) affects the concentrations of Hp, CRP, SAA, alkaline phosphatase (ALKP) and cholesterol, to determine whether these analytes can be used to assess control of HAC following trilostane treatment, and whether a combination of these tests offers a valid method of assessing disease control.
Hp, CRP, SAA, ALKP and cholesterol were assessed in 11 dogs with spontaneous HAC before and after treatment with trilostane. Adequate control of HAC was defined as post-ACTH cortisol less than 150 nmol/l.
Significant reductions in Hp, ALKP, cholesterol and SAA (P<0.05) but not of CRP were found after control of HAC. Only Hp, cholesterol and ALKP were moderately informative (Se & Sp>0.7) of disease control when compared to adrenocorticotropin or corticotropin (ACTH) stimulation test. SAA and CRP were unhelpful (Se & Sp<0.7). The analysis of the combination of the analytes did not improve the correlation with ACTH stimulation test.
Relying on these analytes does not provide additional information over ACTH stimulation test results when assessing control of HAC treated with trilostane.
急性期蛋白（APPs）包括触珠蛋白（Hp）、C反应蛋白（CRP）和血清淀粉样蛋白A（SAA）。犬体内内源性或外源性糖皮质激素可导致Hp浓度升高。
评估控制肾上腺皮质功能亢进（HAC）是否会影响Hp、CRP、SAA、碱性磷酸酶（ALKP）和胆固醇的浓度，确定这些分析物是否可用于评估曲洛司坦治疗后HAC的控制情况，以及这些检测的组合是否提供了一种评估疾病控制的有效方法。
对11只自发性HAC犬在曲洛司坦治疗前后进行Hp、CRP、SAA、ALKP和胆固醇检测。HAC的充分控制定义为促肾上腺皮质激素（ACTH）刺激后皮质醇低于150 nmol/l。
控制HAC后，发现Hp、ALKP、胆固醇和SAA显著降低（P<0.05），但CRP未降低。与促肾上腺皮质激素或促肾上腺皮质素（ACTH）刺激试验相比，只有Hp、胆固醇和ALKP对疾病控制具有中等信息量（敏感性和特异性>0.7）。SAA和CRP无帮助（敏感性和特异性<0.7）。分析物组合的分析并未改善与ACTH刺激试验的相关性。
在用曲洛司坦治疗的HAC控制评估中，依靠这些分析物并不能比ACTH刺激试验结果提供更多信息。
