Department of Trauma and Orthopedic Surgery, HELIOS-Klinikum Wuppertal, Heusnerstr, 40, 42283 Wuppertal, University of Witten/Herdecke, Witten, Germany.
BMC Musculoskelet Disord. 2010 Apr 20;11:75. doi: 10.1186/1471-2474-11-75.
In patients with osteoarthritis, a detailed assessment of degenerative cartilage disease is important to recommend adequate treatment. Using a representative sample of patients, this study investigated whether MRI is reliable for a detailed cartilage assessment in patients with osteoarthritis of the knee.
In a cross sectional-study as a part of a retrospective case-control study, 36 patients (mean age 53.1 years) with clinically relevant osteoarthritis received standardized MRI (sag. T1-TSE, cor. STIR-TSE, trans. fat-suppressed PD-TSE, sag. fat-suppressed PD-TSE, Siemens Magnetom Avanto syngo MR B 15) on a 1.5 Tesla unit. Within a maximum of three months later, arthroscopic grading of the articular surfaces was performed. MRI grading by two blinded observers was compared to arthroscopic findings. Diagnostic values as well as intra- and inter-observer values were assessed.
Inter-observer agreement between readers 1 and 2 was good (kappa = 0.65) within all compartments. Intra-observer agreement comparing MRI grading to arthroscopic grading showed moderate to good values for readers 1 and 2 (kappa = 0.50 and 0.62, respectively), the poorest being within the patellofemoral joint (kappa = 0.32 and 0.52). Sensitivities were relatively low at all grades, particularly for grade 3 cartilage lesions. A tendency to underestimate cartilage disorders on MR images was not noticed.
According to our results, the use of MRI for precise grading of the cartilage in osteoarthritis is limited. Even if the practical benefit of MRI in pretreatment diagnostics is unequivocal, a diagnostic arthroscopy is of outstanding value when a grading of the cartilage is crucial for a definitive decision regarding therapeutic options in patients with osteoarthritis.
在骨关节炎患者中,详细评估退行性软骨疾病对于推荐适当的治疗非常重要。本研究使用具有代表性的患者样本,调查 MRI 对于膝关节骨关节炎患者的详细软骨评估是否可靠。
作为回顾性病例对照研究的一部分,在一项横断面研究中,36 名(平均年龄 53.1 岁)有临床相关骨关节炎的患者接受了标准化的 MRI(矢状 T1-TSE、冠状 STIR-TSE、横断脂肪抑制 PD-TSE、矢状脂肪抑制 PD-TSE,西门子 Magnetom Avanto syngo MR B 15)检查。在最多三个月内,对关节表面进行了关节镜分级。由两位盲法观察者对 MRI 分级与关节镜检查结果进行比较。评估了诊断价值以及观察者内和观察者间的价值。
读者 1 和 2 之间的观察者间一致性在所有关节间隙均较好(kappa = 0.65)。观察者 1 和 2 将 MRI 分级与关节镜分级进行比较,显示出中等至较好的观察者内一致性(kappa 值分别为 0.50 和 0.62),髌股关节的一致性最差(kappa 值分别为 0.32 和 0.52)。所有分级的敏感性相对较低,尤其是 3 级软骨病变。在 MRI 图像上未发现低估软骨病变的趋势。
根据我们的结果,MRI 用于骨关节炎软骨的精确分级是有限的。即使 MRI 在治疗前诊断中的实际益处是明确的,但在需要对软骨进行分级以对骨关节炎患者的治疗选择做出明确决策时,关节镜诊断具有突出的价值。