Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193 CNRS - Université de la Méditerranée, Marseille, France.
Psychol Med. 2011 Feb;41(2):291-9. doi: 10.1017/S0033291710000796. Epub 2010 Apr 21.
The clinical picture of schizophrenia is frequently worsened by manifestations of impulsivity. However, the neural correlates of impulsivity in this disorder are poorly known. Although impulsivity has been related to disturbances of the neural processes underlying response inhibition, no studies have yet examined the relationship between these processes and psychometric measures of impulsivity in schizophrenia. This was the aim of the current investigation.
Event-related functional magnetic resonance imaging in conjunction with a Go/NoGo task was employed to probe the neural activity associated with response inhibition in 26 patients with schizophrenia and 30 healthy comparison subjects. All participants also completed the Barratt Impulsiveness Scale - version 11 (BIS-11). Voxel-wise regression analyses were used to examine the relationship between the BIS-11 score and brain activation during response inhibition in each group.
Patients with schizophrenia were more impulsive than healthy subjects, as indicated by higher BIS-11 scores. Patients, but not healthy subjects, were found to display a positive correlation between these scores and cerebral activation associated with response inhibition. This correlation involves a unique cluster localized within the right ventrolateral prefrontal cortex (VLPFC), a key node of the brain network subserving response inhibition.
We evidenced in patients with schizophrenia that greater BIS-11 scores are associated with greater activation within the right VLPFC during response inhibition. This finding suggests that the efficiency of this brain region to process inhibitory control is reduced in the more impulsive patients.
精神分裂症的临床症状经常因冲动表现而加重。然而，该疾病中冲动的神经相关性知之甚少。尽管冲动与反应抑制的神经过程紊乱有关，但尚无研究探讨这些过程与精神分裂症患者心理测量学冲动之间的关系。这是当前研究的目的。
采用事件相关功能磁共振成像结合 Go/NoGo 任务，探究 26 名精神分裂症患者和 30 名健康对照者的反应抑制相关神经活动。所有参与者还完成了巴瑞特冲动量表-11 版（BIS-11）。体素回归分析用于检验每组中 BIS-11 评分与反应抑制期间大脑激活之间的关系。
精神分裂症患者比健康受试者更冲动，表现为 BIS-11 评分更高。研究发现，患者而不是健康受试者的 BIS-11 评分与反应抑制相关的大脑激活之间存在正相关。这种相关性涉及到一个独特的簇，位于右侧腹外侧前额叶皮层（VLPFC）内，这是反应抑制大脑网络的关键节点。
我们在精神分裂症患者中发现，BIS-11 评分越高，在反应抑制期间右侧 VLPFC 的激活程度越大。这一发现表明，该脑区处理抑制控制的效率在冲动性较高的患者中降低。
