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婴儿期缺铁与 19 岁时的神经认知功能:执行功能和识别记忆长期缺陷的证据。

Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory.

机构信息

Department of Psychology and Social Behavior, University of California, Irvine, California 92697, USA.

出版信息

Nutr Neurosci. 2010 Apr;13(2):54-70. doi: 10.1179/147683010X12611460763689.

Abstract

Iron deficiency in infancy negatively impacts a variety of neurodevelopmental processes at the time of nutrient insufficiency, with persistent central nervous system alterations and deficits in behavioral functioning, despite iron therapy. In rodent models, early iron deficiency impairs the hippocampus and the dopamine system. We examined the possibility that young adults who had experienced chronic, severe, iron deficiency as infants would exhibit deficits on neurocognitive tests with documented frontostriatal (Trail Making Test, Intra-/Extra-dimensional Shift, Stockings of Cambridge, Spatial Working Memory, Rapid Visual Information Processing) and hippocampal specificity (Pattern Recognition Memory, Spatial Recognition Memory). Participants with chronic, severe iron deficiency in infancy performed less well on frontostriatal-mediated executive functions, including inhibitory control, set-shifting, and planning. Participants also exhibited impairment on a hippocampus-based recognition memory task. We suggest that these deficits may result from the long-term effects of early iron deficiency on the dopamine system, the hippocampus, and their interaction.

摘要

婴儿期缺铁会在营养不足时对多种神经发育过程产生负面影响,尽管进行了铁治疗,但仍会持续出现中枢神经系统改变和行为功能缺陷。在啮齿动物模型中,早期缺铁会损害海马体和多巴胺系统。我们研究了这样一种可能性,即那些在婴儿期经历过慢性、严重缺铁的年轻人,在具有明确额-纹状体特异性(连线测试,内/外在维度转换,剑桥套线测验,空间工作记忆,快速视觉信息处理)和海马体特异性(模式识别记忆,空间识别记忆)的神经认知测试中,可能会表现出缺陷。有慢性、严重婴儿期缺铁的参与者在前额纹状体介导的执行功能方面表现较差,包括抑制控制、转换和计划。参与者在基于海马体的识别记忆任务中也表现出损伤。我们认为这些缺陷可能是由于早期缺铁对多巴胺系统、海马体及其相互作用的长期影响所致。

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本文引用的文献

2
Socioeconomic gradients predict individual differences in neurocognitive abilities.
Dev Sci. 2007 Jul;10(4):464-80. doi: 10.1111/j.1467-7687.2007.00600.x.
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Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus.
Neuroimage. 2007 Feb 15;34(4):1643-9. doi: 10.1016/j.neuroimage.2006.11.008. Epub 2006 Dec 15.
5
Iron deficiency and brain development.
Semin Pediatr Neurol. 2006 Sep;13(3):158-65. doi: 10.1016/j.spen.2006.08.004.
7
Iron deficiency in infancy and mother-child interaction at 5 years.
J Dev Behav Pediatr. 2006 Oct;27(5):371-8. doi: 10.1097/00004703-200610000-00001.
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D2 antidopaminergic modulation of frontal lobe function in healthy human subjects.
Biol Psychiatry. 2006 Dec 1;60(11):1196-205. doi: 10.1016/j.biopsych.2006.04.014. Epub 2006 Sep 1.
9
Anemia in low-income exclusively breastfed infants.
J Pediatr (Rio J). 2006 Jul-Aug;82(4):284-7. doi: 10.2223/JPED.1511.
10
Long-lasting neural and behavioral effects of iron deficiency in infancy.
Nutr Rev. 2006 May;64(5 Pt 2):S34-43; discussion S72-91. doi: 10.1301/nr.2006.may.s34-s43.

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