婴儿期缺铁对神经和行为的长期影响。
Long-lasting neural and behavioral effects of iron deficiency in infancy.
作者信息
Lozoff Betsy, Beard John, Connor James, Barbara Felt, Georgieff Michael, Schallert Timothy
机构信息
Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA.
出版信息
Nutr Rev. 2006 May;64(5 Pt 2):S34-43; discussion S72-91. doi: 10.1301/nr.2006.may.s34-s43.
Abstract
Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.
摘要
婴儿缺铁和缺铁性贫血的风险很高。本综述总结了婴儿期缺铁的长期影响的证据。从学龄前到青春期的随访研究报告显示，认知、运动和社会情感功能较差，以及神经生理差异持续存在。动物模型研究指出了这种长期影响的机制。潜在机制与脑发育过程中铁缺乏对神经代谢、髓鞘形成和神经递质功能的影响有关。
相似文献
1
Long-lasting neural and behavioral effects of iron deficiency in infancy.婴儿期缺铁对神经和行为的长期影响。
Nutr Rev. 2006 May;64(5 Pt 2):S34-43; discussion S72-91. doi: 10.1301/nr.2006.may.s34-s43.
2
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function.发育期间缺铁与认知或行为功能缺陷之间因果关系的证据概述。
Am J Clin Nutr. 2007 Apr;85(4):931-45. doi: 10.1093/ajcn/85.4.931.
3
Effect of iron-deficiency anemia on cognitive skills and neuromaturation in infancy and childhood.缺铁性贫血对婴幼儿及儿童认知能力和神经成熟的影响。
Food Nutr Bull. 2003 Dec;24(4 Suppl):S104-10. doi: 10.1177/15648265030244S207.
4
Iron deficiency and child development.缺铁与儿童发育
Food Nutr Bull. 2007 Dec;28(4 Suppl):S560-71. doi: 10.1177/15648265070284S409.
5
6
Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years.婴儿期缺铁与低社会经济地位的双重负担：对19岁前认知测试分数的纵向分析
Arch Pediatr Adolesc Med. 2006 Nov;160(11):1108-13. doi: 10.1001/archpedi.160.11.1108.
7
The interplay between maternal-infant anemia and iron deficiency.母婴贫血与缺铁之间的相互作用。
Nutr Rev. 2023 Mar 10;81(4):480-491. doi: 10.1093/nutrit/nuac066.
8
Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction.早期缺铁会对大脑和行为产生影响，这些影响与多巴胺能功能障碍一致。
J Nutr. 2011 Apr 1;141(4):740S-746S. doi: 10.3945/jn.110.131169. Epub 2011 Feb 23.
9
Iron deficiency during the first 1000 days of life: are we doing enough to protect the developing brain?生命最初 1000 天的铁缺乏：我们是否做足了保护大脑发育的措施？
Proc Nutr Soc. 2022 Mar;81(1):108-118. doi: 10.1017/S0029665121002858. Epub 2021 Sep 22.
10
A review of studies on the effect of iron deficiency on cognitive development in children.缺铁对儿童认知发育影响的研究综述。
J Nutr. 2001 Feb;131(2S-2):649S-666S; discussion 666S-668S. doi: 10.1093/jn/131.2.649S.
引用本文的文献
1
Occurrence and Correlates of Vitamin D and Iron Deficiency in Children with Autism Spectrum Disorder.自闭症谱系障碍儿童维生素D和铁缺乏的发生率及其相关因素
Nutrients. 2025 Aug 23;17(17):2738. doi: 10.3390/nu17172738.
2
Early-life nutritional supplementation protects against home environmental risks in Ghanaian children's social-emotional development.早期营养补充可预防加纳儿童社会情感发展中的家庭环境风险。
Front Nutr. 2025 Aug 20;12:1571677. doi: 10.3389/fnut.2025.1571677. eCollection 2025.
3
Dual Impact of Iron Deficiency and Antibiotics on Host Metabolism: A Tissue-Level Analysis.缺铁与抗生素对宿主代谢的双重影响：组织水平分析
Metabolites. 2025 Aug 14;15(8):549. doi: 10.3390/metabo15080549.
4
Impacts of Food Insecurity on Child Development: Strengthening the Role of Childcare.粮食不安全对儿童发育的影响：强化儿童保育的作用。
Nutrients. 2025 Jul 25;17(15):2427. doi: 10.3390/nu17152427.
5
Serum Levels of Blood Minerals (Fe, Mg) and Vitamins (D, B12) in Suicide Attempters.自杀未遂者的血清血液矿物质（铁、镁）和维生素（D、B12）水平
Iran J Public Health. 2025 Jun;54(6):1282-1290. doi: 10.18502/ijph.v54i6.18906.
6
Potential application of pig () skin peptide-iron chelates in the treatment of iron deficiency anemia and regulation of intestinal flora metabolism.猪（）皮肽铁螯合物在缺铁性贫血治疗及肠道菌群代谢调节中的潜在应用。
需注意，原文中“pig () skin”括号处内容缺失，翻译可能不太准确，建议补充完整准确信息后再进行精准翻译。
Front Nutr. 2025 Jun 13;12:1553668. doi: 10.3389/fnut.2025.1553668. eCollection 2025.
7
Iron and selenium: At the crossroads of development and death in oligodendrocytes.铁与硒：少突胶质细胞发育与死亡的十字路口
Arch Biochem Biophys. 2025 Sep;771:110509. doi: 10.1016/j.abb.2025.110509. Epub 2025 Jun 13.
8
Effect of gestational anemia on breastfeeding- a prospective follow-up -study.妊娠期贫血对母乳喂养的影响——一项前瞻性随访研究
BMC Pregnancy Childbirth. 2025 Jun 4;25(1):653. doi: 10.1186/s12884-025-07775-x.
9
The transfusion of prematures early school age follow-up (TOP 5): protocol for a longitudinal cohort study.早产儿童入学早期随访研究（TOP 5）：一项纵向队列研究方案
BMC Pediatr. 2025 May 15;25(1):387. doi: 10.1186/s12887-025-05732-3.
10
Association of dietary diversity and odds of anemia in children and adolescents: a systematic review and meta-analysis of observational studies.儿童和青少年饮食多样性与贫血几率的关联：观察性研究的系统评价和荟萃分析
BMC Nutr. 2025 Apr 22;11(1):83. doi: 10.1186/s40795-025-01069-3.
本文引用的文献
1
Iron deficiency anemia in infancy is associated with altered temporal organization of sleep states in childhood.婴儿期缺铁性贫血与儿童期睡眠状态的时间组织改变有关。
Pediatr Res. 2007 Dec;62(6):715-9. doi: 10.1203/PDR.0b013e3181586aef.
2
Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain.发育性缺铁对大脑中mRNA表达模式的急性和慢性影响。
J Neural Transm Suppl. 2006(71):173-96. doi: 10.1007/978-3-211-33328-0_19.
3
Double burden of iron deficiency in infancy and low socioeconomic status: a longitudinal analysis of cognitive test scores to age 19 years.婴儿期缺铁与低社会经济地位的双重负担：对19岁前认知测试分数的纵向分析
Arch Pediatr Adolesc Med. 2006 Nov;160(11):1108-13. doi: 10.1001/archpedi.160.11.1108.
4
Effects of iron deficiency in infancy on patterns of motor development over time.婴儿期缺铁对运动发育模式随时间变化的影响。
Hum Mov Sci. 2006 Dec;25(6):821-38. doi: 10.1016/j.humov.2006.06.006. Epub 2006 Oct 16.
5
Iron deficiency in infancy and mother-child interaction at 5 years.婴儿期缺铁与5岁时的母婴互动
J Dev Behav Pediatr. 2006 Oct;27(5):371-8. doi: 10.1097/00004703-200610000-00001.
6
Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats.尽管对围产期缺铁性贫血大鼠进行了早期铁补充，但成年后仍存在持续的神经化学和行为异常。
Behav Brain Res. 2006 Aug 10;171(2):261-70. doi: 10.1016/j.bbr.2006.04.001. Epub 2006 May 19.
7
Moderate iron deficiency in infancy: biology and behavior in young rats.婴儿期中度缺铁：幼鼠的生物学特性与行为表现
Behav Brain Res. 2006 Jun 30;170(2):224-32. doi: 10.1016/j.bbr.2006.02.024. Epub 2006 Mar 29.
8
Growth indices, anemia, and diet independently predict motor milestone acquisition of infants in south central Nepal.生长指标、贫血和饮食状况可独立预测尼泊尔中南部婴儿运动发育里程碑的获得情况。
J Nutr. 2005 Dec;135(12):2840-4. doi: 10.1093/jn/135.12.2840.
9
Explicit memory performance in infants of diabetic mothers at 1 year of age.糖尿病母亲的婴儿1岁时的外显记忆表现。
Dev Med Child Neurol. 2005 Aug;47(8):525-31. doi: 10.1017/s0012162205001039.
10
Iron deficiency: differential effects on monoamine transporters.缺铁：对单胺转运体的不同影响。
Nutr Neurosci. 2005 Feb;8(1):31-8. doi: 10.1080/10284150500047070.
Zotero 插件