Lozoff Betsy, Beard John, Connor James, Barbara Felt, Georgieff Michael, Schallert Timothy
Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA.
Nutr Rev. 2006 May;64(5 Pt 2):S34-43; discussion S72-91. doi: 10.1301/nr.2006.may.s34-s43.
Infants are at high risk for iron deficiency and iron-deficiency anemia. This review summarizes evidence of long-term effects of iron deficiency in infancy. Follow-up studies from preschool age to adolescence report poorer cognitive, motor, and social-emotional function, as well as persisting neurophysiologic differences. Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function.
婴儿缺铁和缺铁性贫血的风险很高。本综述总结了婴儿期缺铁的长期影响的证据。从学龄前到青春期的随访研究报告显示，认知、运动和社会情感功能较差，以及神经生理差异持续存在。动物模型研究指出了这种长期影响的机制。潜在机制与脑发育过程中铁缺乏对神经代谢、髓鞘形成和神经递质功能的影响有关。
