Dasanu Constantin A
Department of Hematology-Oncology, St. Francis Hospital and Medical Center, Hartford, CT, USA.
J Oncol Pharm Pract. 2011 Sep;17(3):282-4. doi: 10.1177/1078155210367839. Epub 2010 Apr 20.
Although rare, cardiac rhythm abnormalities have been documented with bortezomib use in clinical trials. These side effects must be recognized promptly by physicians of various specialties as well as pharmacists. Special attention is required in patients with liver function abnormalities, elderly and patients with pre-existing cardiac conditions. Prompt bortezomib withdrawal is essential in these cases as it may prevent dismal outcomes. This is the first report of a complete heart block caused by bortezomib in the setting of myeloma therapy outside a clinical trial. The author discusses further various heart rhythm and other autonomic nervous system abnormalities attributed to bortezomib in the existing literature.
尽管罕见，但在临床试验中已记录到使用硼替佐米会出现心脏节律异常。各类专科医生以及药剂师必须迅速识别这些副作用。肝功能异常患者、老年人以及已有心脏疾病的患者需要特别关注。在这些情况下，及时停用硼替佐米至关重要，因为这可能避免不良后果。这是关于硼替佐米在临床试验之外的骨髓瘤治疗中导致完全性心脏传导阻滞的首例报告。作者在现有文献中进一步讨论了归因于硼替佐米的各种心律及其他自主神经系统异常情况。
