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硼替佐米成功治疗POEMS综合征，克服了复杂的严重心脏传导阻滞。

Successful treatment with bortezomib for POEMS syndrome, overcoming complicated severe heart block.

作者信息

Nakamura Yuichi, Itoh Yoshihiro, Wakimoto Naoki, Kanno Ryu, Iida Shinichirou, Yamamoto Keiji

机构信息

Department of Hematology Saitama Medical University Hospital Moroyama Japan.

Department of Cardiovascular Medicine Saitama Medical University Hospital Moroyama Japan.

出版信息

Clin Case Rep. 2023 Mar 2;11(3):e7004. doi: 10.1002/ccr3.7004. eCollection 2023 Mar.

DOI:10.1002/ccr3.7004
PMID:36873076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9979967/
Abstract

Cardiac bradyarrhythmia and conduction disorder may be rare, but recurrent adverse events caused by bortezomib. Here we report a case with POEMS syndrome presenting severe heart block after bortezomib plus dexamethasone therapy. After permanent pacemaker implantation, bortezomib was restarted and maintained, resulting in sustained complete response for POEMS syndrome.

摘要

心脏缓慢性心律失常和传导障碍可能少见，但硼替佐米会引发复发性不良事件。在此，我们报告1例POEMS综合征患者，在接受硼替佐米联合地塞米松治疗后出现严重心脏传导阻滞。植入永久性起搏器后，重新开始并维持使用硼替佐米治疗，使得POEMS综合征获得持续完全缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/bbe188bafcc6/CCR3-11-e7004-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/63713c39d14b/CCR3-11-e7004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/679cd3ec151a/CCR3-11-e7004-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/bbe188bafcc6/CCR3-11-e7004-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/63713c39d14b/CCR3-11-e7004-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/679cd3ec151a/CCR3-11-e7004-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f81/9979967/bbe188bafcc6/CCR3-11-e7004-g003.jpg

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