MRC Human Reproductive Sciences Unit, The Queen's Medical Research Institute, Centre for Reproductive Biology, 47 Little France Crescent, Edinburgh EH16 4TJ, UK.
J Endocrinol. 2010 Aug;206(2):141-57. doi: 10.1677/JOE-10-0072. Epub 2010 Apr 20.
Endometrial adenocarcinoma is the most common gynaecological malignancy in western countries. Many of the established risk factors for developing endometrial cancer are associated with excess exposure to oestrogen unopposed by progesterone. These include nulliparity, late onset of the menopause, post-menopausal hormone replacement therapy and obesity. However, a number of risk factors also promote inflammation, another feature proposed to influence cancer development. The human cycling endometrium undergoes regular and cyclical episodes of inflammation. Moreover, hormonal and genetic changes that occur early in the development of endometrial adenocarcinoma can exacerbate the local inflammatory environment. Via alterations in the expression of local mediators and immune cell function, these may contribute to the development of endometrial cancer. This review discusses the contribution of inflammation to the initiation and progression of endometrial adenocarcinoma. Manipulation of inflammatory pathways may therefore represent a therapeutic target in endometrial adenocarcinoma.
子宫内膜腺癌是西方国家最常见的妇科恶性肿瘤。许多已确定的子宫内膜癌发病风险因素与孕激素拮抗的雌激素过度暴露有关。这些因素包括未婚、绝经晚、绝经后激素替代治疗和肥胖。然而，一些风险因素也会促进炎症，另一个被认为会影响癌症发展的特征。人类周期性子宫内膜经历周期性和周期性的炎症发作。此外，在子宫内膜腺癌发展早期发生的激素和遗传变化可加重局部炎症环境。通过局部介质表达的改变和免疫细胞功能，可能有助于子宫内膜癌的发生。本文综述了炎症对子宫内膜腺癌发生和进展的影响。因此，炎症途径的调控可能成为子宫内膜腺癌的治疗靶点。
