Van der Linden Philippe
Department of Anesthesiology, CHU Brugmann - HUDERF, Free University of Brussels, Brussels, Belgium.
Digestion. 2010;82(2):102-5. doi: 10.1159/000285525. Epub 2010 Apr 21.
Sedation is required to treat an ever increasing number of patients for medical diagnostic or therapeutic procedures, in particular in gastrointestinal endoscopy. Due to the apparent ease of administration of sedative techniques, and due to the shortage of anesthetic staff in many Western countries, sedation is being carried out more and more frequently by non-anesthesiologist doctors or even paramedical staff. Due to its pharmacokinetic properties, propofol has become the preferred sedative drug used by non-anesthesiologists. However, uncritical use of propofol by nonqualified persons might result in much higher complications rates and even fatal events. Several guidelines have been published with common issues, but also some significant differences. Whether they contribute to improved patient safety or not will depend on the practical application and interpretation of these guidelines. Although further evaluation is needed, computer-assisted systems might contribute to the safe administration of propofol through a better control of the level of sedation.
在医疗诊断或治疗过程中，尤其是在胃肠内镜检查中，需要对越来越多的患者进行镇静处理。由于镇静技术给药明显简便，且许多西方国家麻醉工作人员短缺，非麻醉医生甚至医护辅助人员进行镇静处理的情况越来越频繁。由于其药代动力学特性，丙泊酚已成为非麻醉医生首选的镇静药物。然而，非专业人员不加审慎地使用丙泊酚可能会导致更高的并发症发生率，甚至致命事件。已经发布了一些指南，这些指南有共同问题，但也存在一些显著差异。它们是否有助于提高患者安全性将取决于这些指南的实际应用和解读。尽管还需要进一步评估，但计算机辅助系统可能通过更好地控制镇静水平有助于丙泊酚的安全给药。
