Falanga V, McKenzie A, Eaglstein W H
University of Miami School of Medicine, Department of Dermatology and Cutaneous Surgery, Miami 33101.
J Dermatol Surg Oncol. 1991 Apr;17(4):336-9. doi: 10.1111/j.1524-4725.1991.tb01707.x.
The pathogenesis of venous ulceration is thought to involve the formation of fibrin cuffs around dermal capillaries. Consistent with a barrier effect of fibrin, it has been shown that the dermal diffusion of oxygen, as measured by transcutaneous oxygen pressure (TcPO2), is decreased in limbs affected by venous ulcer. However, it is unknown whether oxygen diffusion around the perimeter of venous ulcers is uniformly affected. In this study, we investigated TcPO2 values at four different quadrants around the ulcers of 14 patients, the contralateral leg of five patients with unilateral ulcers, and the leg of six normal individuals. These values were also compared to TcPO2 measurements at the chest. Our results indicate that, whereas TcPO2 values in limbs affected by venous ulcers are much lower than normal, there is a great deal of variability in oxygen diffusion around individual ulcers. These findings may represent a heterogeneity in the disease process affecting the leg.
静脉溃疡的发病机制被认为涉及真皮毛细血管周围纤维蛋白套的形成。与纤维蛋白的屏障作用一致，研究表明，通过经皮氧分压（TcPO2）测量，受静脉溃疡影响的肢体中氧气的真皮扩散减少。然而，静脉溃疡周边的氧气扩散是否受到均匀影响尚不清楚。在本研究中，我们调查了14例患者溃疡周围四个不同象限的TcPO2值、5例单侧溃疡患者对侧腿的TcPO2值以及6名正常个体腿部的TcPO2值。这些值还与胸部的TcPO2测量值进行了比较。我们的结果表明，虽然受静脉溃疡影响的肢体中的TcPO2值远低于正常水平，但各个溃疡周围的氧气扩散存在很大差异。这些发现可能代表了影响腿部的疾病过程中的异质性。
