慢性静脉溃疡中的氧扩散

Oxygen diffusion in chronic venous ulceration.

作者信息

Moosa H H, Falanga V, Steed D L, Makaroun M S, Peitzman A B, Eaglstein W H, Webster M W

出版信息

J Cardiovasc Surg (Torino). 1987 Jul-Aug;28(4):464-7.

Abstract

A diffusion barrier to oxygen caused by fibrin deposition around dilated, proliferating capillaries in patients with venous hypertension may contribute to the development of venous ulceration. This diffusion barrier was studied in 18 patients with venous ulcers using the transcutaneous oxygen (TcPO2) monitor (TCM204 Radiometer, America). TcPO2 sensors were placed adjacent to venous ulcers on lower limbs and on the chest and foot of each patient. Readings were taken after a sensor temperature of 44 degrees C was reached (10-15 minutes). TcPO2 values were markedly decreased in skin adjacent to the ulcers (10 +/- 2 mmHg) compared with those of the chest (64 +/- 2 mmHg) and foot (43 +/- 2 mmHg). Inhalation of 100% oxygen for 10 minutes increased chest TcPO2 in all patients (145 +/- 8 mmHg) and increased TcPO2 in skin around the ulcers in 17 of 18 patients (61 +/- 13 mmHg). This study supports the existence of a local pathologic barrier to oxygen diffusion in patients with venous ulcers.

摘要

静脉高压患者扩张、增生的毛细血管周围纤维蛋白沉积所导致的氧气扩散障碍，可能促使静脉溃疡的形成。本研究使用经皮氧分压（TcPO2）监测仪（美国Radiometer公司生产的TCM204型）对18例静脉溃疡患者的这种扩散障碍进行了研究。将TcPO2传感器置于每位患者下肢静脉溃疡旁以及胸部和足部。在传感器温度达到44摄氏度（10 - 15分钟）后进行读数。与胸部（64±2 mmHg）和足部（43±2 mmHg）相比，溃疡旁皮肤的TcPO2值显著降低（10±2 mmHg）。所有患者吸入100%氧气10分钟后，胸部的TcPO2升高（145±8 mmHg），18例患者中有17例溃疡周围皮肤的TcPO2升高（61±13 mmHg）。本研究支持静脉溃疡患者存在局部病理性氧气扩散障碍。