一锅法多组分合成两种新型硫内酯支架。
One-pot multicomponent synthesis of two novel thiolactone scaffolds.
机构信息
Department of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
出版信息
Mol Divers. 2010 Aug;14(3):479-91. doi: 10.1007/s11030-010-9249-2. Epub 2010 Apr 21.
PMID:20407923
Abstract
We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.
摘要
我们设计了两种新型的硫内酯支架。这两种支架都可以通过会聚的 Ugi 多组分反应（MCR）得到，因此适合于文库合成。将报告设计、立体选择性、结构、完整的实验细节和虚拟文库。
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