Shu Vanessa Asoh, Eni Donatus Bekindaka, Ntie-Kang Fidele
Center for Drug Discovery, Faculty of Science, University of Buea, Buea, Cameroon.
Department of Chemistry, Faculty of Science, University of Buea, Buea, Cameroon.
Mol Divers. 2025 Apr;29(2):1737-1760. doi: 10.1007/s11030-024-10883-z. Epub 2024 Jun 4.
The emergence of diverse infections worldwide, which is a serious global threat to human existence, necessitates the urgent development of novel therapeutic candidates that can combat these diseases with efficacy. Molecular hybridization has been established as an efficient technique in designing bioactive molecules capable of fighting infections. Isatin, a core nucleus of an array of compounds with diverse biological properties can be modified at different positions leading to the creation of novel drug targets, is an active area of medicinal chemistry. This review containing published articles from 2005 to 2022 highlights isatin hybrids which have been synthesized and reported in the literature alongside a discussion on their biological properties. The enriched structure-activity relationship studies discussed provides insights for the rational design of novel isatin hybrids with tailored biological properties as effective therapeutic candidates inspired by nature.
全球范围内各种感染的出现对人类生存构成了严重的全球威胁，因此迫切需要开发能够有效对抗这些疾病的新型治疗候选药物。分子杂交已被确立为设计能够对抗感染的生物活性分子的有效技术。异吲哚酮是一系列具有多种生物学特性的化合物的核心结构，可在不同位置进行修饰以产生新的药物靶点，这是药物化学的一个活跃领域。这篇综述涵盖了2005年至2022年发表的文章，重点介绍了文献中已合成并报道的异吲哚酮杂化物，并讨论了它们的生物学特性。所讨论的丰富的构效关系研究为合理设计具有定制生物学特性的新型异吲哚酮杂化物提供了见解，这些杂化物可作为受自然启发的有效治疗候选药物。
