Rivera Daniel G, Wessjohann Ludger A
Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, Germany.
J Am Chem Soc. 2006 Jun 7;128(22):7122-3. doi: 10.1021/ja060720r.
The first 3-fold multicomponent macrocyclizations of trifunctional building blocks were developed to produce, in one pot, cryptands, cages, and cryptophanes with peptoid tethers carrying additional recognition motifs. The straightforward, efficient, and diversity-oriented fashion by which these complex macromulticycles are obtained is suitable for building combinatorial libraries of synthetic receptors with potential applicability in catalysis and supramolecular and coordination chemistry. The strategy also easily allows creation of asymmetric macromulticyclic cavities, with up to 20 new bonds formed in one pot.
开发了三官能团构建块的首个3倍多组分大环化反应，以便在一锅反应中制备带有携带额外识别基序的类肽连接链的穴状配体、笼状化合物和隐窝芳烃。获得这些复杂的大分子多环化合物的直接、高效且面向多样性的方式，适用于构建合成受体的组合文库，在催化、超分子和配位化学中具有潜在应用价值。该策略还能轻松实现不对称大分子多环腔的构建，一锅反应中可形成多达20个新键。
