Max-Planck-Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Biointerphases. 2008 Jun;3(2):FA117. doi: 10.1116/1.2977492.
The authors investigate membrane composition-mediated interactions between proteins adsorbed onto a two-component lipid bilayer close to critical demixing using coarse-grained molecular dynamics simulations and a phenomenological Ginzburg-Landau theory. The simulations consist of three-bead lipids and platelike proteins, which adsorb onto the membrane by binding preferentially to one of the two lipid species. The composition profile around one protein and the pair correlation function between two proteins are measured and compared to the analytical predictions. The theoretical framework is applicable to any scalar field embedded in the membrane, and although in this work the authors treat flat membranes, the methodology extends readily to curved geometries. Neglecting fluctuations, both lipid composition profile and induced protein pair potential are predicted to follow a zeroth order modified Bessel function of the second kind with the same characteristic decay length. These predictions are consistent with our molecular dynamics simulations, except that the interaction range is found to be larger than the single profile correlation length.
作者使用粗粒分子动力学模拟和唯象的吉布斯-朗道理论研究了接近临界分相的两亲双层膜中吸附蛋白的膜成分介导的相互作用。模拟由三链脂质和板状蛋白组成，这些蛋白通过优先与两种脂质之一结合而吸附在膜上。测量了一个蛋白周围的组成分布和两个蛋白之间的对关联函数，并将其与分析预测进行了比较。该理论框架适用于嵌入在膜中的任何标量场，尽管在这项工作中作者处理了平面膜，但该方法很容易扩展到弯曲的几何形状。忽略涨落，脂质组成分布和诱导的蛋白对势都被预测为遵循第二种类的零阶修正贝塞尔函数，其具有相同的特征衰减长度。这些预测与我们的分子动力学模拟一致，只是相互作用范围被发现大于单个分布相关长度。
