Barabash R D, Levitskiĭ A P
Ukr Biokhim Zh (1978). 1978 Jan-Feb;50(1):35-41.
The content of proteins and nucleic acids and activity of acid and alkaline proteases, RNases, phosphatases and alpha-amylase were studied in the gum and alveolar bone or rats at the age of 1, 3, 6, 12, 18 and 24 months. It is found that a degree of periodontal atrophy strongly and directly correlates with the age of rats. The concentration of DNA and RNA in alveolar bone and of RNA in gum decreases with the age. The hydroxyproline content of periodontal tissues continuously increases till the age of 18th month and then considerably decreases. The activity of trypsin-like proteases, cathepsins and alkaline RNase in periodontal tissues increases reaching the maximum at the age of 6-18 months, and the activity of alkaline phosphatase decreases in the process of aging.
研究了1、3、6、12、18和24月龄大鼠牙龈和牙槽骨中蛋白质、核酸的含量以及酸性和碱性蛋白酶、核糖核酸酶、磷酸酶和α-淀粉酶的活性。发现牙周萎缩程度与大鼠年龄呈强烈正相关。牙槽骨中DNA和RNA的浓度以及牙龈中RNA的浓度随年龄增长而降低。牙周组织中羟脯氨酸含量在18月龄前持续增加，之后显著下降。牙周组织中类胰蛋白酶、组织蛋白酶和碱性核糖核酸酶的活性增加，在6 - 18月龄时达到最大值，而碱性磷酸酶的活性在衰老过程中降低。
