Hadassah Hebrew University Medical Center, Department of Anesthesiology and Critical Care Medicine, Jerusalem, POB 12000, Israel.
Expert Opin Drug Deliv. 2010 Jun;7(6):737-52. doi: 10.1517/17425241003767383.
Pain following surgery is often treated by local anesthetic agents. Duration of the analgesia can be extended safely following administration of encapsulated large doses of local anesthetic agents.
This review considers formulations used for encapsulation of local anesthetic agents for prolonged anesthesia effect. All studies describing encapsulation of a commercial local anesthetic agent for providing prolonged analgesia were considered using the NCBI Medline site. of local anesthetic, prolonged anesthesia, polymers and liposomes were entered in order to retrieve appropriate articles and reviews from 1966 to 2010, with emphasis on the last 10 years. Reference pages were searched manually for other relevant articles. The topics covered include an overview of local anesthetic agents and a review of local anesthetic carrier agents, with emphasis on liposomes and polymer carriers. Articles were limited to the English language.
The current research areas for prolongation of local anesthetic effect are evaluated, along with their limitations. Each topic has been summarized, and the review has attempted to cover all current laboratory and clinical studies in a simple manner that should also be useful for readers without a pharmacology background. The direction of research is promising and exciting, and this review should be a useful up-to-date reference.
Many formulations including polymer and liposome carriers have facilitated prolonged local anesthetic action for several days, although few clinical studies have been performed. This field promises a safe way to deliver local anesthetics for effect far beyond that of commercially available agents, with potential cost and health benefits for patients suffering chronic or postoperative pain.
手术后疼痛通常通过局部麻醉剂治疗。局部麻醉剂的封装大剂量给药后，其镇痛作用可以安全延长。
本综述考虑了用于延长局部麻醉剂麻醉作用的制剂。所有描述用于提供延长镇痛的商业局部麻醉剂包封的研究均使用 NCBI Medline 站点进行了考虑。局部麻醉剂、延长麻醉、聚合物和脂质体被输入以检索从 1966 年到 2010 年的适当文章和综述，重点是过去 10 年。手动搜索参考文献页面以获取其他相关文章。涵盖的主题包括局部麻醉剂概述和局部麻醉剂载体剂综述，重点是脂质体和聚合物载体。文章仅限于英语。
评估了延长局部麻醉效果的当前研究领域及其局限性。每个主题都进行了总结，综述试图以一种简单的方式涵盖所有当前的实验室和临床研究，对于没有药理学背景的读者也应该有用。研究方向很有希望和令人兴奋，本综述应该是一个有用的最新参考资料。
许多制剂，包括聚合物和脂质体载体，已经使局部麻醉剂的作用延长了数天，尽管进行了很少的临床研究。该领域有望为患者提供一种安全的方法来提供局部麻醉剂，其效果远远超过市售制剂，具有潜在的成本和健康益处，适用于患有慢性或术后疼痛的患者。
