Paul F. Glenn Laboratory and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aging Cell. 2010 Apr;9(2):285-90. doi: 10.1111/j.1474-9726.2010.00548.x.
The sirtuins are highly conserved NAD-dependent deacetylases that were shown to regulate lifespan in lower organisms and affect diseases of aging in mammals, such as diabetes, cancer, and inflammation. Most relevant to the amelioration of disease, the SIR2 ortholog SIRT1 has been shown to deacetylate many important transcription factors to exert an overarching influence on numerous metabolic pathways. Here we discuss several diseases of aging for which SIRT1 has been recently shown to confer protection. These findings suggest that manipulating sirtuin activity pharmacologically may be a fruitful area to improve human health.
Sirtuins 是高度保守的 NAD 依赖性去乙酰化酶，它们被证明可以调节低等生物的寿命，并影响哺乳动物的衰老相关疾病，如糖尿病、癌症和炎症。与改善疾病最相关的是，SIRT1 的 SIR2 同源物已被证明可以去乙酰化许多重要的转录因子，从而对许多代谢途径产生全面影响。在这里，我们讨论了几种衰老疾病，最近的研究表明 SIRT1 可以为这些疾病提供保护。这些发现表明，通过药理学手段操纵 sirtuin 活性可能是改善人类健康的一个有前途的领域。
